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BIOCHEMISTRY (Theory) | Zoology

BIOCHEMISTRY (Theory)

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Paper Code: 
24ZOL124
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to –

  1. Enlighten the students about the importance of biological macromolecules, structures and configurational properties.
  2. Examine the key role of biochemistry in the metabolic process.

 

 

Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessmen t Strategies

Course Code

Course Title

24ZOL

124

Biochemis try

(Theory)

CO19:Analyze  the   concepts   of

biocatalysts,  enzyme  activity,  its

kinetics,    inhibition    and    redox

reactions.

CO20:Acquire detailed knowledge

about the

Structure,  classification,  physico-

chemical properties and biological

significance,     metabolism      and

metabolic           disorders           of

carbohydrates.

CO21:Illustrate         the         lipid

classification, structure, properties,

anabolic and catabolic pathways of

lipid    metabolism   and           disorders associated with them.

CO22:Classify proteins and amino

acids based on various parameters.

Compare   and   contrast   between

different     levels      of      protein

organization   and    correlate    the

protein sequencing strategies with

its structures.

CO23:Outline   various   catabolic

reactions associated with amino acid

degradation and correlate the inborn

metabolic    disorders   with    their

defective metabolic enzymes and

their consequences.

CO24:Contribute   effectively   in

course-specific interaction

Approach in

teaching:

Interactive

Lectures,

Discussion,

Tutorials,

Reading

assignments,

Demonstration,

Team teaching

Learning

activities for

the students:

Self-learning

assignments,

Effective questions,

Simulation,

Seminar

presentation,

Giving tasks,

Field

practical

Class test

Semester end

examinations,

Quiz,

Assignments,

Presentation

Individual

and group

projects

 

12.00
Unit I: 
UNIT I
  • Biocatalysis
  • Classification and nomenclature of enzymes
  • Mechanism of enzyme action
  • Enzyme Kinetics
  • Inhibition of enzyme
  • Isoenzymes and coenzymes
  • Energy consideration
  • Biological oxidation and reduction
  • Fundamental reactions of biological oxidation
  • Redox potential and Electron transfer system enzymes

 

14.00
Unit II: 
Unit II
  • Carbohydrates
  • Definition, general properties, classification and configuration of carbohydrates
  • Metabolism
  • Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
  • Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
  • Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.

 

 

14.00
Unit III: 
Unit III
  • Carbohydrates
  • Definition, general properties, classification and configuration of carbohydrates
  • Metabolism
  • Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
  • Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
  • Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.

 

 

12.00
Unit IV: 
Unit IV
  • General properties and classification of proteins
  • Amino acid structure and classification
  • Structure of protein-Primary, Secondary, Tertiary And Quaternary
  • Ramachandran plots
  • Globular and fibrous protein- motif in globular proteins
  • Protein Sequencing

 

10.00
Unit V: 
Unit V
  • Protein metabolism
  • Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
  • Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.

 

Essential Readings: 
  • U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
  • Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
  • Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
  • Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
  • Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
  • Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.W.H. Freeman and Co

 

References: 
SUGGESTED READINGS:
Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia
:Wolters Kluwer Health
Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
 
E-RESOURCES:
e-PGPATHSHALA-INFLIBNET CENTRE
Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php
 
e-JOURNAL:
Journal of Biochemistry- ISSN 1756-2651
Biochemistry- ACS Publication- ISSN 1520-4995
Journal of Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644
 
Academic Year: