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BIOCHEMISTRY (Theory)
Course objectives:
This course will enable the students to –
- Enlighten the students about the importance of biological macromolecules, structures and configurational properties.
- Examine the key role of biochemistry in the metabolic process.
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Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessmen t Strategies |
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Course Code |
Course Title |
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24ZOL 124 |
Biochemis try (Theory) |
CO19:Analyze the concepts of biocatalysts, enzyme activity, its kinetics, inhibition and redox reactions. CO20:Acquire detailed knowledge about the Structure, classification, physico- chemical properties and biological significance, metabolism and metabolic disorders of carbohydrates. CO21:Illustrate the lipid classification, structure, properties, anabolic and catabolic pathways of lipid metabolism and disorders associated with them. CO22:Classify proteins and amino acids based on various parameters. Compare and contrast between different levels of protein organization and correlate the protein sequencing strategies with its structures. CO23:Outline various catabolic reactions associated with amino acid degradation and correlate the inborn metabolic disorders with their defective metabolic enzymes and their consequences. CO24:Contribute effectively in course-specific interaction |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching Learning activities for the students: Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical |
Class test Semester end examinations, Quiz, Assignments, Presentation Individual and group projects |
- Biocatalysis
- Classification and nomenclature of enzymes
- Mechanism of enzyme action
- Enzyme Kinetics
- Inhibition of enzyme
- Isoenzymes and coenzymes
- Energy consideration
- Biological oxidation and reduction
- Fundamental reactions of biological oxidation
- Redox potential and Electron transfer system enzymes
- Carbohydrates
- Definition, general properties, classification and configuration of carbohydrates
- Metabolism
- Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
- Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
- Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.
- Carbohydrates
- Definition, general properties, classification and configuration of carbohydrates
- Metabolism
- Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
- Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
- Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.
- General properties and classification of proteins
- Amino acid structure and classification
- Structure of protein-Primary, Secondary, Tertiary And Quaternary
- Ramachandran plots
- Globular and fibrous protein- motif in globular proteins
- Protein Sequencing
- Protein metabolism
- Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
- Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.
- U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
- Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
- Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
- Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
- Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
- Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.W.H. Freeman and Co
