BIOCHEMISTRY

Paper Code: 
25ZOL124
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
This course will enable the students to –
1. Enlighten the students about the importance of biological macromolecules, structures and configurational properties.
2. Examine the key role of biochemistry in the metabolic process.
 
Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessmen t Strategies

Course Code

Course Title

 

 

 

 

 

 

 

 

 

 

 

 

 

 

25ZOL124

Biochemistry

(Theory)

CO19:Analyze    the                          concepts                          of

biocatalysts, enzyme  activity,  its

kinetics,    inhibition    and                 redox

reactions.

CO20:Acquire detailed knowledge

about the

Structure,  classification,  physico-

chemical properties and biological

significance,      metabolism                         and

metabolic           disorders                          of

carbohydrates.

CO21:Illustrate         the                                 lipid

classification, structure, properties,

anabolic and catabolic pathways of

lipid    metabolism and disorders associatedwith

them.

CO22:Classify proteins and amino

acids based on various parameters.

Compare    and    contrast                 between

different      levels       of                   protein

organization    and                       correlate                       the

protein sequencing strategies with

its structures.

CO23:Outline    various                          catabolic

reactions associated with amino acid

degradation and correlate the inborn

metabolic    disorders                   with                   their

defective metabolic enzymes and

their consequences.

CO24:Contribute                               effectively                          in

course-specific interaction

Approach in

teaching:

Interactive

Lectures,

Discussion,

Tutorials,

Reading

assignments,

Demonstration,

Team teaching

Learning

activities for

the students:

Self-learning

assignments, Effective questions,

Simulation,

Seminar

presentation,

Giving tasks,

Field

practical

Class test

Semester end

examinations,

Quiz,

Assignments,

Presentation

Individual

and group

projects

 

 

 

 

12.00
Unit I: 
UNIT I
● Biocatalysis
● Classification and nomenclature of enzymes
● Mechanism of enzyme action
● Enzyme Kinetics
● Inhibition of enzyme
● Isoenzymes and coenzymes
● Energy consideration
● Biological oxidation and reduction
● Fundamental reactions of biological oxidation
● Redox potential and Electron transfer system enzymes
 
14.00
Unit II: 
UNIT II
● Carbohydrates
● Definition, general properties, classification and configuration of carbohydrates
● Metabolism
● Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
● Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
● Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.
 
12.00
Unit III: 
UNIT III
● Lipids
● Definition, general properties and classification
● Structure and importance of-:
● Simple lipids- fats and wax
● Compound lipids- phospholipids, glycolipids, amino lipids and sulpholipids o Steroids- cholesterol, bile acids, steroid hormones
● Lipoproteins
● Lipid Metabolism
● Beta oxidation and Lipogenesis.
● Inborn errors of metabolism: Niemann pick disease,TaySach’sdisease,Gaucher’s disease, Krabbe’s disease
 
12.00
Unit IV: 
UNIT IV:
● General properties and classification of proteins
● Amino acid structure and classification
● Structure of protein-Primary, Secondary, Tertiary And Quaternary
● Ramachandran plots
● Globular and fibrous protein- motif in globular proteins
● Protein Sequencing
 
10.00
Unit V: 
UNIT V
● Protein metabolism
● Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
● Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.
 
Essential Readings: 
● U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
● Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
● Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
● Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
● Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
● Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.
W.H. Freeman and Co
 
References: 
SUGGESTED READINGS:
● Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia
:Wolters Kluwer Health
● Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
● Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
● Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
● Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
● Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
● H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
 
E-RESOURCES:
● e-PGPATHSHALA-INFLIBNET CENTRE
● Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php
 
e-JOURNAL:
● Journal of Biochemistry- ISSN 1756-2651
● Biochemistry- ACS Publication- ISSN 1520-4995
● Journal of Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644 
 
 
 
Academic Year: 
2025-2026
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