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BIOCHEMISTRY | Zoology

BIOCHEMISTRY

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Paper Code: 
25ZOL124
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
This course will enable the students to –
1. Enlighten the students about the importance of biological macromolecules, structures and configurational properties.
2. Examine the key role of biochemistry in the metabolic process.
 
Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessmen t Strategies

Course Code

Course Title

 

 

 

 

 

 

 

 

 

 

 

 

 

 

25ZOL124

Biochemistry

(Theory)

CO19:Analyze    the                          concepts                          of

biocatalysts, enzyme  activity,  its

kinetics,    inhibition    and                 redox

reactions.

CO20:Acquire detailed knowledge

about the

Structure,  classification,  physico-

chemical properties and biological

significance,      metabolism                         and

metabolic           disorders                          of

carbohydrates.

CO21:Illustrate         the                                 lipid

classification, structure, properties,

anabolic and catabolic pathways of

lipid    metabolism and disorders associatedwith

them.

CO22:Classify proteins and amino

acids based on various parameters.

Compare    and    contrast                 between

different      levels       of                   protein

organization    and                       correlate                       the

protein sequencing strategies with

its structures.

CO23:Outline    various                          catabolic

reactions associated with amino acid

degradation and correlate the inborn

metabolic    disorders                   with                   their

defective metabolic enzymes and

their consequences.

CO24:Contribute                               effectively                          in

course-specific interaction

Approach in

teaching:

Interactive

Lectures,

Discussion,

Tutorials,

Reading

assignments,

Demonstration,

Team teaching

Learning

activities for

the students:

Self-learning

assignments, Effective questions,

Simulation,

Seminar

presentation,

Giving tasks,

Field

practical

Class test

Semester end

examinations,

Quiz,

Assignments,

Presentation

Individual

and group

projects

 

 

 

 

12.00
Unit I: 
UNIT I
Biocatalysis
Classification and nomenclature of enzymes
Mechanism of enzyme action
Enzyme Kinetics
Inhibition of enzyme
Isoenzymes and coenzymes
Energy consideration
Biological oxidation and reduction
Fundamental reactions of biological oxidation
Redox potential and Electron transfer system enzymes
 
14.00
Unit II: 
UNIT II
Carbohydrates
Definition, general properties, classification and configuration of carbohydrates
Metabolism
Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
Inborn errors of metabolism: Galactosemia, Lactose Intolerance, Glycogen storage diseases.
 
12.00
Unit III: 
UNIT III
Lipids
Definition, general properties and classification
Structure and importance of-:
Simple lipids- fats and wax
Compound lipids- phospholipids, glycolipids, amino lipids and sulpholipids o Steroids- cholesterol, bile acids, steroid hormones
Lipoproteins
Lipid Metabolism
Beta oxidation and Lipogenesis.
Inborn errors of metabolism: Niemann pick disease,TaySach’sdisease,Gaucher’s disease, Krabbe’s disease
 
12.00
Unit IV: 
UNIT IV:
General properties and classification of proteins
Amino acid structure and classification
Structure of protein-Primary, Secondary, Tertiary And Quaternary
Ramachandran plots
Globular and fibrous protein- motif in globular proteins
Protein Sequencing
 
10.00
Unit V: 
UNIT V
Protein metabolism
Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.
 
Essential Readings: 
U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.
W.H. Freeman and Co
 
References: 
SUGGESTED READINGS:
Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia
:Wolters Kluwer Health
Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
 
E-RESOURCES:
e-PGPATHSHALA-INFLIBNET CENTRE
Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php
 
e-JOURNAL:
Journal of Biochemistry- ISSN 1756-2651
Biochemistry- ACS Publication- ISSN 1520-4995
Journal of Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644 
 
 
 
Academic Year: