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Biochemistry | Zoology

Biochemistry

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Paper Code: 
ZOL 124
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 124

Biochemistry

The students will –

CO17: Analyse the concepts of biocatalysts, enzyme activity and its kinetics.

CO18: Acquire detailed knowledge about the structure, classification, physico-chemical properties and biological significance of carbohydrates, amino acids, proteins and lipids.

CO19: Illustrate the anabolic and catabolic pathways of different cellular biomolecules, rate-limiting steps and energetic pathways.

CO20: Correlate the defective enzymes and inborn errors of metabolism.

CO21: Assess the role of biomolecules in the metabolic processes.

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

Class test

Semester end examinations, Quiz,

Assignments,

Presentation

Individual and group projects

 

12.00
Unit I: 
UNIT I

Biocatalysis

  • Classification and nomenclature of enzymes
  • Mechanism of enzyme action
  • Enzyme Kinetics
  • Inhibition of enzyme
  • Isoenzymes and coenzymes
  • Energy consideration
Biological oxidation and reduction
  • Fundamental reactions of biological oxidation
  • Redox potential and Electron transfer system enzymes

 

12.00
Unit II: 
UNIT II
Carbohydrates
  • Definition, general properties, classification and configuration of carbohydrates
Metabolism
  • Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
  • Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis

Inborn errors of metabolism:

  • Galactosemia
  • Lactose Intolerance
  • Glycogen storage diseases.
12.00
Unit III: 
UNIT III
Lipids
  • Definition, general properties and classification

Structure and importance of-:

  • Simple lipids- fats and wax
  • Compound lipids- phospholipids, glycolipids, amino lipids and sulpholipids
  • Steroids- cholesterol, bile acids, steroid hormones
  • Lipoproteins
  • Lipid Metabolism
  • Beta oxidation andLipogenesis.

Inborn errors of metabolism:

  • Niemann pick disease
  • TaySach’sdisease
  • Gaucher’s disease
  • Krabbe’s disease
14.00
Unit IV: 
UNIT IV
 Proteins
  • General properties and classification of proteins
  • Amino acid structure and classification
  • Structure of protein-Primary, Secondary, Tertiary And Quaternary
  • Ramachandran plots
  • Globular and fibrous protein- motif in globular proteins
  • Protein Sequencing
10.00
Unit V: 
UNIT V

Protein metabolism    

  • Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
  • Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.
Essential Readings: 

ESSENTIAL READINGS:

  • U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
  • Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
  • Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
  •  Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman  and Co.
  •  Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi. ● Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.  W.H. Freeman and Co
SUGGESTED READINGS:
● Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia :Wolters Kluwer Health
● Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition,  John Wiley & Sons, Inc. 
● Principles of Biochemistry; Smith et.al; McGraw Hill, New York. 
● Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient  Longman, Madras 
● Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.  
Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.  
● H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.  
 
 
E-RESOURCES: 
e-PGPATHSHALA-INFLIBNET CENTRE-
Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php
 
e-JOURNAL: 
Journal of Biochemistry- ISSN 1756-2651
 Biochemistry- ACS Publication- ISSN 1520-4995
Journal of Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644

 

Academic Year: