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Biochemistry
Course Outcomes (COs):
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Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
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ZOL 124 |
Biochemistry |
The students will – CO17: Analyse the concepts of biocatalysts, enzyme activity and its kinetics. CO18: Acquire detailed knowledge about the structure, classification, physico-chemical properties and biological significance of carbohydrates, amino acids, proteins and lipids. CO19: Illustrate the anabolic and catabolic pathways of different cellular biomolecules, rate-limiting steps and energetic pathways. CO20: Correlate the defective enzymes and inborn errors of metabolism. CO21: Assess the role of biomolecules in the metabolic processes. |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching Learning activities for the students: Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical |
Class test Semester end examinations, Quiz, Assignments, Presentation Individual and group projects |
Biocatalysis
- Classification and nomenclature of enzymes
- Mechanism of enzyme action
- Enzyme Kinetics
- Inhibition of enzyme
- Isoenzymes and coenzymes
- Energy consideration
- Fundamental reactions of biological oxidation
- Redox potential and Electron transfer system enzymes
- Definition, general properties, classification and configuration of carbohydrates
- Catabolism of glucose with Stoichiometry, Glycolysis, Krebs cycle and Cori’s cycle
- Phosphogluconate pathways (Pentose Phosphate Pathway) Glycogenesis, Glycogenolysis and Gluconeogenesis
Inborn errors of metabolism:
- Galactosemia
- Lactose Intolerance
- Glycogen storage diseases.
- Definition, general properties and classification
Structure and importance of-:
- Simple lipids- fats and wax
- Compound lipids- phospholipids, glycolipids, amino lipids and sulpholipids
- Steroids- cholesterol, bile acids, steroid hormones
- • Lipoproteins
- • Lipid Metabolism
- Beta oxidation andLipogenesis.
Inborn errors of metabolism:
- Niemann pick disease
- TaySach’sdisease
- Gaucher’s disease
- Krabbe’s disease
- General properties and classification of proteins
- Amino acid structure and classification
- Structure of protein-Primary, Secondary, Tertiary And Quaternary
- Ramachandran plots
- Globular and fibrous protein- motif in globular proteins
- Protein Sequencing
Protein metabolism
- Amino acid degradation: Deamination reaction- Oxidative and non oxidative deamination reaction, Transamination and Trans deamination, Decarboxylation, Ornithine cycle of urea formation, Fate of carbon skeleton of amino acids(Metabolism of individual amino acid excluded)
- Inborn errors of metabolism: Alkaptonuria, Phenylketonuria, Maple Syrup, Tyrosinemia, Albinism, Urea Disorders.
ESSENTIAL READINGS:
- U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
- Jain,J.L. Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
- Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
- Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
- Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi. ● Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition. W.H. Freeman and Co
