SPECIAL PAPER: HUMAN GENETICS- II

Paper Code: 
ZOL 423 D
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to -

  1. To provide students with a detailed  knowledge of Organization of the human genome; Genes and chromosome structure, function and inheritance, Genetic variation, Immunogenetics, Extranuclear genetics, Human Genome Project, Genetic counseling

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 423 D

 

Genetics- II

Development of Students with a detailed  knowledge of:

CO107: Organization of the human genome; Genes and chromosome structure,
function and inheritance

CO108:Genetic variation, Immunogenetics, Extranuclear genetics

CO109:Human Genome Project, Genetic counseling

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

Class test

Semester end examinations,

Quiz

Assignments,

Presentations

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I

Genetic variation – History, Categories of mutations,  chromosome and gene mutations, Extrachromosomal mutations, Mutator genes, Mobile genetic elements, Induced mutations, Physical and chemical mutagenes,  Molecular basis of spontaneous and induced mutations, DNA repair mechanisms, Reversion, Transposon mutagenesis, In vitro mutagenesis, Environmental mutagenesis
Chromosome rearrangements and Cancer.

Chromosomal aberration :

Numerical : Aneuploidy, Polyploidy  

Structural : Translocation, Duplication, Inversion, Ring Chromosome and Deletion  

Others : Mosaic, Chimera [Individual with two cell lines]

12.00
Unit II: 
UNIT II

Immunogenetics - 

Genetics of normal immune system. Inherited immunodeficiency, eg. X-linked

agammaglobulinaemia. Major Histocompatibility Complex – Study of Twins (MHC), HLA disease associations. Tranplantation, graft –versus-host disease.

Pharmacogenetic – Definition, gene loci influencing drug metabolism and pharmacogenetic interactions

12.00
Unit III: 
UNIT III

Extranuclear genetics-Role of organellar genome, maternal inheritance and maternal effect.

Stem cell research and cloning 

Source and isolation of stem cells ,Use of stem cells in human welfare ,Making stem cell lines :Methodology ,Whole body cloning ,Organ Cloning

12.00
Unit IV: 
UNIT IV

Human Genome Project 

History, Organization and goals of Human Genome Project 

Human Genome Project  : Friend and Foe ,Repetitive DNA in human genome –Alu and SINE repeats Human genome mapping- Physical, Genetic and Microsatellite mapping,

12.00
Unit V: 
UNIT V

Genetic counseling    

Components of genetic counseling, Legal and ethical considerations

risk assessment and counseling in common Mendelian and multifactor syndromes; 

Genetic testing: biochemical & molecular tests: in children, Presymptomatic testing for late onset diseases (predictive medicine); Prenatal and Preimplantation screening  and diagnosis: Indications for prenatal diagnosis, Indications for chromosomal testing, 

Noninvasive methods (Ultrasound, Embryoscopy, MRI, etc.); Invasive methods; Prenatal screening for Down’s syndrome (maternal  serum) & Neural tube defect; Pre-implantation genetic diagnosis; Ethical issues in pre-natal screening & diagnosis.

Study of Eugenics 

    • Negative Eugenics

    • Positive Eugenics

Essential Readings: 

Books Recommended –

Snustad& Simmons, Principles of Genetics, 4th Edition, Wiley, 2005.

Hartl and Jones, Genetics-Principles and Analysis, 4th Edition, Jones & Bartlett, 1998.

Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland 2007.

Lewin, Genes IX, 9th Edition , Jones & Bartlett, 2007.

Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald, 2005.

Mange and Mange, Basic Human Genetics, 2nd Edition, SinauerAssoc, 1999.

Vogel and Motulsky, Human Genetics, 3rd Edition, Springer Verlag, 1997.

Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci. Publishing, 2004.

How1ey and Mori, The Human Genome, Academic Press, 1999.

Advanced Molecular Biology Twiman

Molecular Cloning Part- 1 Manniatis

Molecular Cloning Part - 2 Manniatis

Molecular Cloning Part - 3 Manniatis

Structural Chemistry and Molecular Biology :Alexander Rich and Norman Davidson

The Chemical Foundations of Molecular James D. Watson

Biology of the Gene (2nd ed.) Molecular Biology of the Cell :Lewis and Watson

Recombinant DNA :Witkowski

Genes VI :Benjamin Lewin

Principles of gene Manipulation : R. W. Old and Primrose

Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N. Davidson

Genes VII :Benjamin Lewin

Human Genetics: Concepts and Applications by Lewis R (2001) McGrawHi; Boston.

Basic Human Genetics by E.J. Manage and A.P. Manage (1997 India Reprint) Rastogi Publications, Meerut.

Mendelian inheritance in Man: Catalogs of Autosomal recessive, and x-linked phenotypes.[12th editions –1998 ] byMcKusick, V.A. Johns Hopkins university press, Baltimore.

 

Academic Year: 
2020-2021
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