Molecular Biology

Paper Code: 
ZOL 213
Credits: 
3
Contact Hours: 
3.00
Max. Marks: 
100.00
9.00
 

Chromosomes: Morphology, Chromonema, Chromomeres, Telomeres, Primary & secondary constrictions, Chromatids

Chromosome type- Polytene & Lampbrush
 

Chromosomal Organization: Euchromatin, Heterochromatin , Nucleosome concept

7.00

Nucleosides, Nucleotides

DNA, RNA

DNA structure(A, B, Z type)

 

10.00

Replication of prokaryotes (Semi-conservative mechanism: Experiments of Messelson & Stahl )

Prokaryotic Polymerases, Topoisomerases, Single stranded binding protein, Replication forks(Unidirectional & Bidirectional), Leading & lagging strand, RNA primers & Okazaki fragments
 

Brief Idea of Eukaryotic Replication

 

10.00

Prokaryotic Transcription: RNA Polymerases, Transcription factors.

  • Transcription termination
  • Mechanism of transcription
  • Post Transcriptional modification in RNA: Capping; Polyadenylation and splicing
 

 

9.00


Genetic Code

Prokaryotic translation

Translational Machinery

Translational Initiation, Elongation and termination

 

Essential Readings: 
  • Becker, W.M., Kleinsmith, L.J., Hardin. J. and Bertoni, G. P. (2009). The World of the Cell. VII Edition. Pearson Benjamin Cummings Publishing, San
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts,
  • Peter Walter: Molecular Biology of the Cell, IV Edition.
  • Cooper G. M. and Robert E. Hausman R. E. The Cell: A Molecular Approach, V Edition, ASM Press and Sinauer Associates.
  • De Robertis, E.D.P. and De Robertis, E.M.F. (2006). Cell and Molecular Biology. VIII Edition. Lippincott Williams and Wilkins, Philadelphia.
  • Karp, G. (2010) Cell and Molecular Biology: Concepts and Experiments. VI Edition. John Wiley and Sons. Inc.
  • Lewin B. (2008). Gene XI, Jones and Bartlett
  • McLennan A., Bates A., Turner, P. and White M. (2015). Molecular Biology IV Edition. GS, Taylor and Francis Group, New York and London.
  • Molecular Biology of the gene; Watson J.D.; Benzamin/ Cummings.
  • Molecular Cell biology (2nd Edition) J. Darnell, H. Lodish and D.Baltimore, Scientific American Books,USA,1994.
  • Cell & Molecular Biology, (8th edition), E D P Roberties & E M F Roberties,  Lippincott Williams & Wilkins, 2005
  • Cell and Molecular Biology, (3rd edition), P Sheeler and D E Bianchi, John Wiley & Sons, Inc, 1987
  • The cell. A Molecular Approach, (4th edition), G H Cooper and R E Hausman, ASM Press, 2007
Academic Year: 
2018-2019
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