Course objectives:
This course will enable the students to –
1. Appraise the detailed knowledge of our immune system to defend against invading pathogens in a logical fashion.
2. Differentiate and evaluate between innate and acquired immunity; Humoral and cell mediated immunity and the consequences of its failure like autoimmunity, hypersensitivity and immunodeficiencies.
3. Develop an understanding about the role of effector cells and molecules of the immune system as complements and antibodies.
Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Course Code |
Course Title |
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25DZOL 501(A) |
Immuno logy (Theory) |
CO49: Distinguish primary and secondary lymphoid organs and various cells of the Immune system and differentiate between immunogens and antigens. CO50: Distinguish the major cellular and tissue components which comprise the innate and adaptive immune system. compare and contrast between systemic and organ specific autoimmune disease and judge the role of vaccines in artificial and natural immunity. CO51: Examine & interpret various forms of antibody- antigen interactions and correlate the structure of different classes of antibodies with their effector functions. CO52: Evaluate the role of MHC in self restriction and could differentiate between endogenous and exogenous antigen presentation and develop the understanding about the centralized role of cytokines in immunity. CO53: Summarize the role of complements in innate and adaptive immunity and could assess the various kinds of hypersensitive reactions and their consequences. CO54:Contribute effectively in course- specific interaction |
The approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration , Team teaching Learning activities for the students: Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Chart preparation |
Assessment Strategies Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation. |
Historical perspective of Immunology, Cells and organs of the Immune system Antigenicity and immunogenicity, Immunogens, Adjuvants and haptens, Factors influencing immunogenicity B and T-Cell epitopes
Innate immunity-Anatomical barriers, Inflammation, Cell and molecules involved in innate immunity Adaptive immunity-Cell mediated and humoral immunity
Active and Passive immunity: Artificial and natural Immunity, Vaccines and its types
Structure and functions of different classes of immunoglobulins, Antibody mediated effector functions
Antigen antibody interactions: precipitation, agglutination, Immunoassays (ELISA )
Structure and functions of MHC molecules.
Endogenous and exogenous pathways of antigen processing and presentation Properties and functions of cytokines
Components and pathways of complement activation.
Gell and Coombs’ classification and brief description of various types of hypersensitivities.
Immune dysfunctions: Brief account of autoimmunity and AIDS.
● Roitt’s essential Immunology, P. Delves, et al., 11th ed., Blackwell Publishing, 2006 ∙
● Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006). Immunology, VI Edition. W.H. Freeman and Company.
● David, M., Jonathan, B., David, R. B. and Ivan R. (2006). Immunology,VII Edition, Mosby, Elsevier Publication.
● Abbas, K. Abul and Lechtman H. Andrew (2017) Cellular and Molecular Immunology. V Edition. Elsevier; 9th edition
e-CONTENT:
● Immunology- ePG pathshala- Inflibnet centre-
● https://epgp.inflibnet.ac.in/Home/ViewSubject?ca tid=2rAs1Puvga4LW93zMe83aA == ∙ Immunology-NPTEL- https://nptel.ac.in/courses/102103038
e-JOURNAL:
● Immunology- Wiley online Library- ISSN 1365-2567
● Scandinavian Journal of Immunology-Online ISSN: 1365-3083