IMMUNOLOGY

Paper Code: 
24DZOL501(A)
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
Course objectives:
 
This course will enable the students to –
 
1. Appraise the detailed knowledge of our immune system to defend against invading  pathogens in a logical fashion. 
 
2. Differentiate and evaluate between innate and acquired immunity; Humoral and cell  mediated immunity and the consequences of its failure like autoimmunity,  hypersensitivity and immunodeficiencies.
 
3. Develop an understanding about the role of effector cells and molecules of the immune  system as complements and antibodies.

 

Course Outcomes: 

Course

Learning outcomes

(at course level)

Learning and  teaching 

strategies

Assessment

Strategies

 Course 

Code

Course Title

24DZOL501(A)

 

Immunology (Theory)

CO49: Distinguish primary and secondary lymphoid organs and various cells of the Immune system and differentiate between immunogens and antigens.

CO50: Distinguish the major cellular and tissue components which comprise the innate and adaptive immune system. compare and contrast between systemic and organ specific autoimmune disease and judge the role of vaccines in artificial and natural immunity.

CO51: Examine &

interpret various forms of antibody-antigen interactions and correlate the structure of different classes of antibodies with their effector functions.

CO52:Evaluate the role of MHC in selfrestrictionand could differentiate between endogenous and exogenous antigen presentation and develop the understanding about the centralized role of cytokines in immunity.

CO53: Summarize the role of complements in innate and adaptive immunity and could assess the various kinds of hypersensitive reactions and their consequences.

CO54:Contribute effectively in course-specific interaction

The approach  in teaching:

Interactive 

Lectures, 

Discussion, 

Tutorials, 

Reading 

assignments,  Demonstration,  Team teaching Learning 

activities for  the students:

Self-learning 

assignments,  Effective 

questions, 

Simulation, 

Seminar 

presentation,  Giving tasks,  Chart 

preparation

Assessment 

Strategies

Class test,  Semester end  examinations, 

Quiz, Solving  problems in  tutorials, 

Assignments, 

Presentation.

 

12.00
Unit I: 
Overview of Immune System & Antigens
Historical perspective of Immunology, 
Cells and organs of the Immune system
Antigenicity and immunogenicity, Immunogens, 
Adjuvants and haptens, 
Factors influencing immunogenicity 
B and T-Cell epitopes
12.00
Unit II: 
Innate and Adaptive Immunity
Innate immunity-Anatomical barriers, Inflammation, Cell and molecules involved in innate immunity 
Adaptive immunity-Cell mediated and humoral immunity 
Immune dysfunctions (brief account of autoimmunity with reference to Rheumatoid Arthritis and tolerance, AIDS). 
Passive: Artificial and natural Immunity, Active: Artificial and natural Immunity, Vaccines and its types 
 
 
 
12.00
Unit III: 
Immunoglobulins
Structure and functions of different classes of immunoglobulins, 
Antibody mediated effector functions 
Antigen antibody interactions: precipitation, agglutination, Immunoassays (ELISA )
12.00
Unit IV: 
Major Histocompatibility Complex & Cytokines

Structure and functions of MHC molecules.

Endogenous and exogenous pathways of antigen processing and presentation

Properties and functions of cytokines, Therapeutics Cytokines

 

12.00
Unit V: 
Complement System & Hypersensitivity
Components and pathways of complement activation. 
Gell and Coombs’ classification and brief description of various types of hypersensitivities 
 
 
Essential Readings: 
ESSENTIAL READINGS: 
Roitt’s essential Immunology, P. Delves, et al., 11th ed., Blackwell Publishing, 2006 ∙ 
Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006). Immunology, VI Edition. W.H. Freeman and Company. 
 
SUGGESTED READINGS: 
David, M., Jonathan, B., David, R. B. and Ivan R. (2006). Immunology,VII Edition, Mosby, ElsevierPublication. 
Abbas, K. Abul and Lechtman H. Andrew (2017) Cellular and Molecular Immunology. V Edition. Elsevier; 9th edition 
 
e-CONTENT: 
Immunology- ePG pathshala- Inflibnet centre- 
 
e-JOURNAL: 
Immunology- Wiley online Library- ISSN 1365-2567 
Scandinavian Journal of Immunology-Online ISSN: 1365-3083
Academic Year: