Coming soon
Genetics & Biostatistics
Course objectives:
This course will enable the students to –
- Understand the patterns of Mendelian inheritance and Interactions of Genes and their expressions.
- Describe role of crossing over and linkage in heredity
- Describe cytoplasmic inheritance and its importance.
- Understand the role of genetics in human welfare and genetic counseling.
- Understand how natural polymorphism and genetic variation can give rise to mutant genes, and how these genetic errors are inherited;
- Describe the scope and application of Biostatistics and Use of data analysis methods.
Course Outcomes (COs):
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Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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ZOL-214 |
Genetics & Biostatistics |
The students will be able to CO 36: Understand the patterns of Mendelian inheritance and Interactions of Genes and their expressions. CO 37: Describe the role of crossing over and linkage in heredity. Describe cytoplasmic inheritance and its importance. CO 38: Understand the role of genetics in human welfare and genetic counseling. CO 39: Understand how natural polymorphism and genetic variation can give rise to mutant genes, and how these genetic errors are inherited;
CO 40: Describe the scope and application of Biostatistics and Use of data analysis methods. |
The approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration,
Learning activities for the students: Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks,
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Class test Semester end examinations, Quiz, Assignments, Presentation Surprise test Open book test
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Mendelian inheritance patterns & laws of heredity
Co and incomplete dominance
Interactions of Genes- Supplementary, Complementary, Duplicate, Epistasis(dominant & recessive)
Multiple alleles-Coat colour in rabbit, Human blood group-ABO & Rh
Gene expression- Lethal genes, Pleiotropic genes
Multiple genes- Seed coat in wheat, skin colour in human
Linkage & construction of linkage maps
Crossing over- Mechanism, theories, Cytological detection & significance
Cytoplasmic inheritance
Human genetics- Chromosomal & single gene disorder, Genetics counseling, Amniocentesis
Eugenics & Euthenics
Determination of Sex – Chromosomal mechanism & environmental influence, the sexual function of X &Y chromosome, Gyandromorphs, Genic Balance Theory,
Sex linked inheritance in man & Drosophila, Y linked genes, Sex limited genes, Sex influenced genes
Mutations- Chromosomal aberrations, Gene mutations
Introduction, scope and application of Biostatistics
Frequency distribution
Graphical presentation of data (bar diagram, frequency polygon, histogram, pie chart)
Mean. mode, median and their significance
Standard deviation ,variance and coefficient of variance
Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)
- A Textbook of Genetics; Rastogi, V.B.; Ramnath & Kedarnath.
- Genetics: Gupta P.k.; Rastogi publication.
- Cell and Molecular Biology; Phillip Sheeler, Donald E. Bianchi; John Wiley and Sons.
- Biostatistics; Gupta, S.P.;Sultan Chand &Co.
Suggested Readings:
- Genetics; Winchester, A.M; Oxford and IBH Publishing Co.
- Genetics; Strickberger; Macmillan, Prentice Hall of India.
- Principles of Genetics; Gardener, E,J; Wiley eastern, New Delhi.
- Primose, S.B. Tyman, R.M. and Old, R.W. Principles of gene manipulation, Willey- Blacwell.
- Cell and Molecular Biology; Gerald Kar cp; John Wiley and Sons,inc
- A Textbook of Genetics; Rastogi, V.B.; Ramnath & Kedarnath.
- Molecular Biology of the cell; Bruce Alberts, Julian Lewis, James D.Watson; Garland Publishings
- Bencroft, H. Introduction to Biostatistics Harper and Row. New York, 1957.
- Bailey, N.T.J. Statistical method in Biology Low Priced Text Book English Language Society, London, 1959.
- Bishop O.N. Statistics for biology, Prentice Hall Press
- Mahajan B.K., Methods in Biostatistics, Jaypee.
