ENVIRONMENTAL TOXICOLOGY I

Paper Code: 
24ZOL323C
Credits: 
4
Contact Hours: 
4.00
Max. Marks: 
100.00
Objective: 
Course objectives:
This course will enable the students to –
1. Analyze detailed understanding of different branches of toxicology
2. Educated about toxicants present in nature and their effect on the environment and living organisms.
 
Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Course Code

Course Title

 

 

 

 

 

 

 

 

 

 

24ZOL

323C

 

 

 

 

 

 

 

 

 

 

Environmental Toxicology I

(Theory)

CO97. List the different                    branches and

principles of Toxicology CO98. Explain

mechanism     of                       toxic agents

CO99. Analysis of Specific    response                of toxicity.

CO100. Evaluate target organ toxicity

CO101.                         Discover physicochemical

nature of toxicants and effect of toxic agents CO102.                       Contribute effectively   in                    course- specific interaction

Approach in teaching: Interactive Lectures, Reading assignments,

 

Learning activities for the students: Effective questions, Simulation,

Seminar presentation,

Class test Semester                 end examination, Viva

 

10.00
Unit I: 
UNIT I
History and Scope of Toxicology Principles of Toxicology
Different Areas of Toxicology
Classification of Toxic Agent
Spectrum of Undesired Effects Interaction of Chemicals
Additive
Synergistics
Potentiation
Antagonism Dose Response Individual or Graded
Response Relationships
 
Quantal Dose
Dose Response Curves Variation in Toxic Responses
Selective Toxicity
Species Differences
Individual Differences Animal Toxicity Tests
Acute
Subacute
Sub chronic
Chronic
Development and Reproductive Toxicology
Mutagenicity
Skin and Eye Irritation
 
15.00
Unit II: 
Unit II
Mechanisms of Toxicity
Delivery
Absorption
Distribution
Excretion
Cellular Dysfunctions and result and toxicities
Repair or Dysrepair Biotransformation of Xenobiotics
Phase I Enzymes (Hydrolysis, Reduction,Oxidation
Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acetylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation) Risk Assessment
Hazard Identifications (Assessing Toxicity Of Chemicals)
Risk Characterization
Risk Perception & comparative Analysis of Risk
Environmental Impact Assessment
 
10.00
Unit III: 
Unit III
Specific Responses of Toxicity
Carcinogenesis
Mutagenicity (Genetic Toxicology)
Teratogenicity (Development Toxicity)
 
15.00
Unit IV: 
Unit IV
Target Organ Toxicity
Liver
Kidney
Nervous System
Blood
 
10.00
Unit V: 
Unit V
Physicochemical nature & Effect of Toxic Agents
Pesticides: (General account) Organochlorine Compound, Anticholinesterase agents and Pyrethroids esters
Metals (Arsenic, Lead, Mercury)
Industrial Solvents (General Account)
Radiation & Radioactive Materials
 
Academic Year: