Environmental Toxicology I

Paper Code: 
ZOL 323 C
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 323C

Environmental Toxicology I

 

Students will –

CO82: Describe different branches of toxicology

CO83: Analysis of Toxicant present in the nature and their effect on environment and living organisms

CO84 : Explain about types of Toxicity

CO85: Perceive principles of Toxicology

CO86: Discover mechanism,  Physicochemical nature of Toxicants and Effect of Toxic Agents

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

 

Learning activities for the students:

Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

Class test

Semester end examinations,

Viva

 

10.00
Unit I: 
UNIT I

History and Scope of Toxicology Principles of Toxicology

  • Different Areas ofToxicology
  • Classification of ToxicAgent
  • Spectrum of Undesired Effects Interaction ofChemicals
  • Additive
  • Synergistics
  • Potentiation
  • Antagonism DoseResponse

Individual or Graded

  • ResponseRelationships
  • QuantalDose
  • Dose Response Curves Variation in Toxic Responses
  • SelectiveToxicity
  • SpeciesDifferences
  • Individual Differences Animal ToxicityTests
  • Acute
  • Subacute
  • Subchronic
  • Chronic
  • Development and ReproductiveToxicology
  • Mutagenicity
  • Skin and EyeIrritation
15.00
Unit II: 
UNIT II
Mechanisms of Toxicity
● Delivery
● Absorption
● Distribution
● Excretion
● Cellular Dysfunctions and result and toxicities
● Repair or Dysrepair Biotransformation ofXenobiotics
● Phase I Enzymes (Hydrolysis, Reduction,Oxidation
● Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acetylation,Amino-acid conjugation Glutathione Conjugation, Phosphorylation)
Risk Assessment
● Hazard Identifications (Assessing Toxicity Of Chemicals)
● RiskCharacterization
● Risk Perception & comparative Analysis ofRisk
● Environmental Impact Assessment
 
10.00
Unit III: 
UNIT III

Specific Responses of Toxicity

  • Carcinogenesis
  • Mutagenicity (Genetic Toxicology)
  • Teratogenicity (Development Toxicity)
15.00
Unit IV: 
UNIT IV

Target Organ Toxicity

  • Liver
  • Kidney
  • Nervous System
  • Blood
10.00
Unit V: 
UNIT V

Physicochemical nature & Effect of Toxic Agents

  • Pesticides: (General account) Organochlorine Compound, Anticholinesterase agents and Pyrethroids esters
  • Metals (Arsenic, Lead, Mercury)
  • Industrial Solvents (General Account)
  • Radiation & Radioactive Materials
Academic Year: 
2023-2024
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