Cell and Molecular Biology

Biomembranes.

• Phospholipids : main lipid constituent.
• Cytosolic and exoplasmic face of biomembranes.
• Intrinsic and extrinsic proteins.

•  Glycolipids.
• Mobility of lipids and integral proteins
• Fluidity of bio membrane.
• Cell Junctions (Gap, tight and desmosomes )

Transport across cell membrane.

•   Diffusion of small molecules.

• Osmosis and water channels.

• Uniporter-catalyzed transport.
• Active Transport.

• Cotransport by symporters and antiporters.

Cytoskeleton:Structure ,Function and Dynamics of

• Microfilaments:Actin and Myosin

• Microtubule and mitosis.
• Kinesin and Dynein.
• Intermediate Filaments

Cilia and Flagella.

• Structure and movements

Cell-Cell Signaling.

• Endocrine, paracrine, autocrine signaling.

• Receptor    Proteins-    Intracellular receptors.

     Cell surface receptors-G-protein coupled    receptors, ion channel receptors, tyrosine kinase  linked  receptors and receptors with
intrinsic enzymatic activity.

• Second messenger system-cAMP and IP3 DAG and MAP kinase pathways.

Signal-Mediated transport through Nuclear Pore.

• Nuclear Pore Complex.

• Nuclear export signals.

Cell-Cell adhesion and communication.

• Cadherin mediated Ca- dependent homophilic cell-cell adhesion.

• N-CAMs mediate Ca-independent homophilic cell-cell adhesion.

•  Connexin.

Cell matrix adhesion.

• Integrins

• Collagen

• Non-collagen   components   of   extracellular   matrix  

Cell cycle.

• Eukaryotic cell cycle-Gl, S, G2 and M phases.

• Cell cycle and check points.

• Molecular basis of cell cycle regulation.

  Cyclins and cyclin-dependent kinases.