CANCER AND RADIATION BIOLOGY II (Theory)

Paper Code: 
24ZOL423A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
Course objectives:
This course will enable the students to -
1. Develop an understanding of types of cancer and their causes.
2. Differentiate and evaluate the role of radiations in cancer and their treatment.
 
Course Outcomes: 

Course Outcomes (COs):

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Course Code

Course Title

24ZOL

423A

Cancer

And Radiatio

n Biology

II

(Theory)

 

CO157. Develop skills,

concepts   and    experience   to

understand types of cancer and

their causes

CO158. List various preventive

measures and therapies of cancer

CO159. Develop an

understanding of acute radiation effects.

CO160. Analyze delayed effects

of radiations.

CO161. Evaluate the radiation

safety measures and regulatory

aspects.

CO162. Contribute effectively in

course-specific interaction

Approach in

teaching:

Interactive Lectures,

Reading assignments,

Team teaching

Learning activities

for the students:

Self-learning assignments,

Effective questions,

Seminar presentation

Class test

Semester   end

examinations,

Quiz

Assignments,

Presentations

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I
Causation of cancer:
● Hereditary cancer.
● Virus and cancer
● Chemical carcinogenesis
● Hormones and cancer
● Nutrition and cancer
● Radiation carcinogenesis
Basic concept of free radicals and their role in cancer
12.00
Unit II: 
Unit II
 
Therapy of cancer.
● Surgical removal
● Chemotherapy
● Radiotherapy.
● Immunotherapy
● Hyperthermia. Management of therapy of cancer. Prevention of cancer.
● Primary prevention: Education, motivation, legislation.
● Secondary prevention.
Detection of precancerous and early cancerous lesions Chemoprevention.
 
12.00
Unit III: 
Unit III
Acute radiation effects.
● Concept of LD50.
● Central nervous system syndrome.
● Gastro-intestinal syndrome.
● Bone Marrow syndrome.
Skin reactions.
 
12.00
Unit IV: 
Unit IV
Delayed effects of Radiation.
● Stochastic and deterministic effects.
● Radiologicaging,
● Life shortening.
● Radiation carcinogenesis.
 
12.00
Unit V: 
Unit V
Radiation safety and regulator aspects.
● Radiographic installations.
● Enclosed installations.
● Field installations.
● Personnel management.
● Source storage facilities.
● Safe work practice.
● Recommendations ofNational/international statutory bodies
 
Essential Readings: 
● Ramesha Rao. : Who runs the risk of cancer.ShipraPublication.
● Alberts. B. Bras D. lenis J. : Molecular Biology of the cells. Govland Publishing NewYork.
● Devita VT. Cancer Prevention. Hellmos. Rosensey. S.A. J.B.Lippincott.
 
References: 
SUGGESTED READINGS:
● Hall. E. J. Radiobiology for the radio biologists. Lippincott. Philadelphia.
● P.S. Lotran. V. Kumar. T.collins. : Pathology of DiseasesRobbins.
● Peekham. M.. Herbert M. Pinedo. Umberto Veronesi. : Oxford textbook of oncology Vol.I.. Vol. II. Oxford Medical Publication. Oxford University Press. Inc. New York1995.
● Tannode. 1 F and Richand P. : The Basic science of oncology. ThII. MacGraw-Hill
● Vinay Kumar. Ramzi. S. Cotran and Stranley L. Robbins. : Basic pathology. Thomson press Ltd.. NOIDA. 1999.
● Weiss. L. : Principles of metastases. Acdemic press.
E-RESOURCES:
● https://ccr.cancer.gov/radiation-biology- branch#:~:text=Intentional%20or%20accidental%20exposure%20of,after%20the%20exposure
%20has%20occurred.
 
JOURNALS:
 
Academic Year: 
2024-2025
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