Coming soon
Biochemistry I
Course objectives:
This course will enable the students to –
- Describe properties of water, acid-base nature and types of chemical bonds.
- Describe Structure, classification and cellular metabolic pathways of carbohydrate and lipids.
- Describe the principles of bioenergetics and enzyme catalysis along with factors affecting enzyme activity.
- Build on their knowledge and understanding about Inborn errors of carbohydrate metabolism, lipid metabolism vitamin deficiency diseases.
Course Outcomes (COs):
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Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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ZOL 114 |
Biochemistry I |
Students will be able to CO 15: Describe properties of water, acid - base nature, and types of chemical bonds. CO 16: Describe Structure, classification and cellular metabolic pathways of carbohydrate and lipids. CO 17: Describe the principles of bioenergetics and enzyme catalysis along with factors affecting enzyme activity. CO 18: Build on their knowledge and understanding about Inborn errors of carbohydrate metabolism, lipid metabolism vitamin deficiency diseases.
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The approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching
Learning activities for the students: Self-learning assignments, presentation, Giving tasks,
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Class test Semester end examinations, Quiz, Assignments, Presentation Surprise test Open book test
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Water as a solvent, Ionization of water, weak acid and weak bases
pH and buffer
Types of chemical bonding:-
Electrovalent ,Covalent and non- covalent bond, H-Bond, Van der Waals interaction, Hydrophobic interactions
Carbohydrates
Classification, Structure & properties (monosaccharides and polysaccharides)
Metabolism- Oxidation of glucose through Glycolysis, Krebs cycle, Gluconeogenesis, Pentose phosphate pathway and Oxidative phosphorylation(ETC).
Glycogenesis and Glycogenolysis
Lipids
Classification, (Fatty acids, triglycerides, phospholipids, sphingolipids, Gangliosides, Glycolipids.)
Structure and properties
Biosynthesis of Triglycerides, Biosynthesis of Palmitic acid
Beta-oxidative pathway of fatty acids
Enzymes:
Classification, Properties
Mechanism of Enzyme action, activation energy
Kinetics (Michaelis-Menton Equation)
Factors affecting enzyme action
Enzyme Inhibition (Competitive and Non- competitive)
Inborn errors of carbohydrate metabolism:Galactosemia, Lactose Intolerance, Glycogen storage diseases
Inborn errors of lipid metabolism: Niemann pick disease, TaySach’sdisease,Gaucher’s disease, Krabbe’s disease
Vitamins: Occurrence, Function, Requirement, Deficiency diseases
✔ U. Satyanaryana . Biochemistry IV Edition, Elsevier (2013)
✔ Jain,J.L.Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
✔ Murray, R.K.,Harper’s Biochemisttry;Appleton and Lange ,Norwalk,Connecticut.
✔ Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.
✔ Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman and Co.
Suggested Readings:
✔ Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition, John Wiley & Sons, Inc.
✔ Widmaier, E.P., Raff, H. and Strang, K.T. (2008)
✔ Vander’s Human Physiology, XI Edition., McGraw Hill
✔ Principles of Biochemistry; Smith et.al; McGraw Hill, New York.
✔ Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient Longman, Madras
✔ Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York.
✔ Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.
✔ LubertStryer, Biochemistry International Student edition W.H. Freeman and Company, New York.
✔ Metzler, D. Biochemistry, Academic Press.
✔ Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi.
✔ Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition. W.H. Freeman and Co.
✔ Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2009). Harper’s Illustrated Biochemistry. XXVIII Edition. Lange Medical Books/Mc Graw Hill.
✔ H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.
Text Book of Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.
