Genetics & Biostatistics

Paper Code: 
ZOL-214
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Objectives- The course objectives to provide students with a basic understanding of:

  1. Mendelian inheritance patterns & laws of heredity, Interactions of Genes and their expressions.
  2. Process of Crossing over and linkage in genes
  3. What are cytoplasmic inheritance and its importance.
  4. Human genetics and  Genetics counseling,
  5. What is Eugenics & Euthenics
  6. Chromosomes involved in Sex determination
  7. Chromosomal aberrations and Mutations.
  8. Use of data analysis methods including graphing and statistical analysis.

Learning outcomes- By the end of the course, students will be able to:

  1. Understand the patterns of Mendelian inheritance and Interactions of Genes and their expressions.
  2. Describe role of crossing over and linkage in heredity
  3. Describe cytoplasmic inheritance and its importance.
  1. Understand the role of genetics in human welfare and genetic counseling.
  1. Understand how natural polymorphism and genetic variation can give rise to mutant genes, and how these genetic errors are inherited;
  2. Describe the scope and application of Biostatistics and use of data analysis methods

 

9.00

Mendelian inheritance patterns & laws of heredity

Co and incomplete dominance

Interactions of Genes- Supplementary, Complementary, Duplicate, Epistasis(dominant & recessive)

Multiple alleles-Coat colour in rabbit, Human blood group-ABO & Rh

Gene expression- Lethal genes, Pleiotropic genes

Multiple genes- Seed coat in wheat, skin colour in human

7.00

Linkage & construction of linkage maps

Crossing over- Mechanism, theories, Cytological detection & significance

Cytoplasmic inheritance

Human genetics- Chromosomal & single gene disorder, Genetics counseling, Amniocentesis

Eugenics & Euthenics

10.00

Determination of Sex – Chromosomal mechanism & environmental influence, the sexual function of X &Y chromosome, Gyandromorphs, Genic Balance Theory,

Sex linked inheritance in man & Drosophila, Y linked genes, Sex limited genes, Sex influenced genes

Mutations- Chromosomal aberrations, Gene mutations

10.00

Introduction, scope and application of Biostatistics

Frequency distribution

Graphical presentation of data (bar diagram, frequency polygon, histogram, pie chart)

9.00

Mean. mode, median and their significance

Standard deviation ,variance and coefficient of variance

Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)

Essential Readings: 

Essential Readings:

  • A Textbook of Genetics; Rastogi, V.B.; Ramnath&Kedarnath.
  • Genetics: Gupta P.k.; Rastogi publication.
  • Cell and Molecular Biology; Phillip Sheeler,   Donald E. Bianchi; John Wiley and Sons.
  • Biostatistics; Gupta, S.P.;Sultan Chand &Co.
References: 

Suggested Readings:

  • Genetics; Winchester, A.M; Oxford and IBH Publishing Co.
  • Genetics; Strickberger; Macmillan, Prentice Hall of India.
  • Principles of Genetics; Gardener, E,J; Wiley eastern, New Delhi.
  • Primose, S.B. Tyman, R.M. and Old, R.W. Principles of gene manipulation, Willey- Blacwell.
  • Cell and Molecular Biology; Gerald Karp; John Wiley and Sons,inc
  • A Textbook of Genetics; Rastogi, V.B.; Ramnath&Kedarnath.
  • Molecular Biology of the cell; Bruce Alberts, Julian Lewis, James D.Watson; Garland Publishings
  • Bencroft, H. Introduction to Biostatistics Harper and Row. New York, 1957.
  • Bailey, N.T.J. Statistical method in Biology Low Priced Text Book English Language Society, London, 1959.
  • Bishop O.N. Statistics for biology, Prentice Hall Press
  • Mahajan B.K., Methods in Biostatistics, Jaypee.
Academic Year: 
2019-2020
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