Immunology

Paper Code: 
ZOL-512
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Objectives

The course material has been prepared to help the students-

  1.  To understand the ability of our immune system to defend against invading pathogens in a logical fashion. 
  2. To explain the structure of antibodies and its types; cells and organs of immunity.
  3. This includes our innate ability to defend against microorganisms (innate immunity); will this first line of defense fail, how we can fight infections (acquired immunity); if we react excessively, what price we pay (hypersensitivity); if we misdirect our defense, what the consequences are  (autoimmunity) and very importantly, can we prevent pathogens from infecting us (vaccination).

 

Learning outcomes-

At the end of the course, the students will be able to:

  1. Conceptualize how the innate and adaptive immune responses coordinate to fight invading pathogens.
  2. Determine what immunomodulatory strategies can be used to enhance immune responses or to suppress unwanted immune responses such as might be required in hypersensitivity reactions, transplantations or autoimmune diseases.
7.00
Unit I: 
UNIT I

Immunology

  • Definition
  • Types of immunity: innate and acquired
  • Antigen: Antigenicity of molecules, Immunogenicity and its properties, haptens, adjuvants.
8.00
Unit II: 
UNIT II

Antibody

  • Definition.
  • Structure , effector function
  • (IgG. IgM. IgD. IgA and IgE)
  • Properties and function of each class of immunoglobulin.
  • Isotype, Allotype, Ideotype

Antigen-antibody reactions

  • Precipitation reaction
  • Agglutination reaction
10.00
Unit III: 
UNIT III

Cells  and organs of Immunity

  • Primary and Secondary lymphoid organs
  • Dendritic cells
  • Macrophages.
  • Lymphocytes (B- and T- types). T.- Helper cells. T-killer cells, plasma cells and memory cells
12.00
Unit IV: 
UNIT IV
  • MHC genes and gene products.
  • Mechanism of Humoral& Cell mediated  immune response

Complement and its action

8.00
Unit V: 
UNIT V
  • Autoimmunity : Hashimoto thyroiditis, Myasthenia gravis, Rheumatoid arthritis, Lupus
  • Immunodeficiency: AIDS- causes, symptoms, treatment, mode of infection, HIV lifecycle
  • Hypersensitivity-  Type I to IV
  • Cvtokines:  Types, Properties and Function.
Essential Readings: 
  • Kuby, Immunology, W.H. Freeman and Company.
References: 
  • D.M. Wear, Immunology ELBS (English) Language Book Society Low  Priced edition, Longman Singapore Publishers Ltd.
  • Iyan M. Roitt Essential Immunology EIBS Low Priced Edition Black
  • Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006).  Immunology, VI  Edition. W.H. Freeman and Company.
  • David, M., Jonathan, B., David, R. B. and Ivan R. (2006).  Immunology,VII Edition, Mosby, Elsevier Publication.
  • Abbas, K. Abul and Lechtman H. Andrew (2003.) Cellular and Molecular  Immunology. V Edition. Saunders Publication.
Academic Year: 
2019-2020
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