Toxicology

Paper Code: 
LSC 143B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
10.00
Unit I: 
UNIT I :

History and scope of Toxicology

1.    Environmental Toxicology

2.    Economic Toxicology

3.    Forensic Toxicology

Different areas of Toxicology

Classification of Toxic Agents

15.00
Unit II: 
UNIT II :

Disposition of Toxicants

  • Absorption, Distribution & Excretion of Toxicants

Mechanisms of Toxicity

·         Delivery

·         Absorption

·         Distribution

·         Excretion

·         Cellular Dysfunctions and resultant toxicities

·         Repair or Dysrepair

Biotransformation of Xenobiotics

·         Phase I Enzymes (Hydrolysis, Reduction, Oxidation

·         Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acelylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation )       

15.00
Unit III: 
UNIT III

Target Organ Toxicity

  • Liver
  • Blood

Physicochemical nature & Effect of Toxic Agents

·                  Pesticides

·                  Metals

·                  Bioaccumulation and Biomagnification of Toxicants

10.00
Unit IV: 
UNIT IV

Non-Organ-Directed Toxicity

  • Chemical Carcinogenesis
  • Genetic Toxicology
10.00
Unit V: 
UNIT V

Environmental Toxicology

  • Air Pollution
  • Ecotoxicology : Chemodynamics, Biomarker
  •   Terrestrial and Aquatic Ecotoxicology 
 

 

Essential Readings: 
• Casarett and Daull’s Toxicology: The basic science of poisons. By : Curtis D. Klaassen 6th Edn., McGraw-Hill (Medical Publishing Div. NewYork
• Environmental Biotechnology – by. Indu Shekhar Thakur, I.K. International Pub.(2006)
• Toxicology, Principles and Applications: Raymond I.M.. CRC Publication.
• Microbial Ecology: Fundamentals and Applications by Atlas Bartha (An imprint of Addison Wesley Longman Inc) 
• Environmental Microbiology: Maier R.M., Academic Press. 2000 Press, Cambridge. 1993. 
• Environmental Science- A global concern; Cunningham W.P. and Saigo B.W Win. C. Brown Publishers, London, 1995. 
• Advances in Industrial Waste Water Treatment; P.K. Goel; Technoscience Publications. Jaipur, 1999. 
• An Introduction to Air Pollution; Trivedy R.K. and Goel P.K., Technoscience Publications, Jaipur, 1995. 
• Problems of Environment Management in India; Goel M.M., Sharma M.C. and Purohit N.K; Anupriya Publishing House, Jaipur, 1999. 
• Environmental Science (A study of interrelations); Enger E.D. and Smith B.F.;  Win. C. Brown Pub. (Latest Edition).  
• Botkin D. And Keller E. Environmental Science. Earth as a Living Planet; Botkin D. And Keller E
 
Academic Year: 
2021-2022
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