SPECIAL PAPER – Environmental Toxicology I

Paper Code: 
ZOL 323C
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
10.00
Unit I: 
UNIT I

History and Scope of Toxicology

Principles of Toxicology

·         Different Areas of Toxicology

·         Classification of Toxic Agent

·         Spectrum of Undesired Effects

Interaction of Chemicals

·         Additive

·         Synergistics

·         Potentiation

·         Antagonism

Dose Response

·         Individual or Graded

·         Response Relationships

·         Quantal Dose

·         Dose Response Curves

Variation in Toxic Responses

·         Selective Toxicity

·         Species Differences

·         Individual Differences

Animal Toxicity Tests

·         Acute

·         Subacute

·         Subchronic

·         Chronic

·         Development and Reproductive Toxicology

·         Mutagenicity

Skin and Eye Irritation

15.00
Unit II: 
UNIT II

Mechanisms of Toxicity

·         Delivery

·         Absorption

·         Distribution

·         Excretion

·         Cellular Dysfunctions and resultant toxicities

·         Repair or Dysrepair

Biotransformation of Xenobiotics

·         Phase I Enzymes (Hydrolysis, Reduction, Oxidation

·         Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acelylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation)

Risk Assessment

·         Hazard Identifications (Assessing Toxicity of Chemicals)

·         Risk Characterization

·         Risk Perception & comparative Analysis of Risk

Environmental Impact Assessment

10.00
Unit III: 
UNIT III

Specific Responses of Toxicity

·         Carcionogenesis

·         Mutagenecity (Genetic Toxicology)

Teratogenecity (Development Toxicity)

15.00
Unit IV: 
UNIT IV

Target Organ Toxicity

·         Liver

·         Kidney

·         Nervous System

Blood

10.00
Unit V: 
UNIT V

Physicochemical nature & Effect of Toxic Agents

  • Pesticides: (General account )Organochlorine Compound, Antocholinesterase agents and pyrethroids esters
  • Metals (Arsenic,Lead, Mercury)
  • Industrial Solvents(General account)
  • Radiation & Radioactive materials

 

Academic Year: