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Reproductive Biology
Paper Code:
LSC 144C
Credits:
4
Contact Hours:
60.00
Max. Marks:
100.00
12.00
Unit I:
UNIT I
Biology of Spermatozoa and Ovum: Structure, Development and Function :
• The female reproductive system: anatomy and physiology of the mammalian ovary and ductal system. Follicular growth, ovarian hormones, two cell theory of estrogen biosynthesis. Autocrine, Paracrine and endocrine regulation of ovarian functions.
• The male reproductive system: anatomy and physiology of the mammalian testis and the sex accessory glands; Functional Organization of testis, spermatogenic cycle. Testicular androgens, autocrine, paracrine,and endocrine regulation of testicular functions. Semen and its biochemical nature
12.00
Unit II:
UNIT II
Regulation of reproduction :
• The pituitary gland : Functional cytology,
denohypophyseal hormones, their chemistry and
physiology
• The Hypothalamus and its neurosecretory centres:
Structure of neurosecretory cells, the hypothathalamic
principles: synthesis, storage, release and chemistry.
• The phenomenon of neuroendocrine integration and
the hypothalamo- hypophyseal- gonadal axis.
• Role of Thyroid, Pineal and Adrenal glands in
reproduction
• Miscellaneous factors affecting reproduction: nutrition. light, temperature, pheromones, environmental disruptors.
12.00
Unit III:
UNIT III
Diagnosis of male infertility
• Semen analysis: Physical examinations, microscopic examinations, biochemical analysis, Immunological tests.
• Sperm function tests: Sperm mitochondrial Hypo-Osmotic Swelling (HOS)Test, Acrosome, reaction. Acrosome Intactness (AI) test.
• Endocrinological diagnosis.
12.00
Unit IV:
UNIT IV
Reproductive Toxicology:
• Female reproduction-(Hypothalamus, ovary
assessment of female reproductive functions),
• Male reproduction-(Biology of male reproduction,
assessment of male reproductive function)
12.00
Unit V:
UNIT V
Reproductive Techniques:
• Assisted Reproductive Technology (ART)
• Super ovulation, Oocyte collection.
• Collection and preparation of sperm for assisted
fertilization.
➢ Insemination.
➢ In- vitro fertilization and related techniques (IVF, GIFT, ZIFT, TET, ICSl ).
• Cryopreservation of semen, oocytes and embryos.
• Teratological effects of Xenobiotics
• Pre-natal diagnosis
• Impact of aging, Hormone Replacement Therapy
Essential Readings:
Books Recommended:
▪ Ball, G.H. Davidson, J.N. & Scarburough, H.,:Text book of physiology & Biochemistry E. & S. Livingstone Ltd. London (1956). .
▪ Bast, C.H. & Tayler, N.B. :Physiological basis of medical practices, Dilkins Co. Baltimore. (1957).
▪ Guyton A.G.:Text book of Medical Physiology, 7th ed. Saunders Publishers (1986).
▪ Hoar, W.S. :General and comparative Animal physiology 3rd ed. Prentice Hall, Pvt. Ltd. New Delhi (1983).
▪ Scheer: General Physiology
Schmidt Nielsen, K. Animal Physiology, Adaptations & Environment, Cambridge Univ. Press (1975).
▪ Tumer CII. General Endocrinology. W.B. Daunders, Tippan Co. Ltd. Tokyo, Japan (1966).
▪ Schmidt Nielsen, K.: Animal Physiology, Adaptations & Environment Cambridge Press (1975).
▪ Tumer CII: General Endocrinology, W.B. Saunders, Tippan Co. Ltd. Tokyo, Japan (1966).
▪ General and Comparative Endocrinology, E.J.W. Barrington. Oxford. Clarendon Press.
▪ Text Book of Endocrinology, R.H. Williams. W.B. Saunders.
▪ Endocrine Physiology. C.R. Martin. Oxford Univ. Press.
▪ Assali,N.S.: Biology of Gestation.VolI and II. Academic press, New York.
▪ Birkhead T.K. and Moller A.P. :Sperm competition and sexual selection. Academic press,London,1998.
▪ Cole, H.h. ,Cupps P.T.: Reproduction in domestic animals.
▪ Dorfman, R.I.: Methods in hormone research (Vol I and Vol II) . Academic press, New York.1962.
▪ Edwards R.G. and Brody S,A.: Principles and practice of assisted human reproduction. W.b. Saunders Co., Philadelphia,1995.
Academic Year:
