Molecular Biology & Genetics II

Paper Code: 
ZOL 202
Contact Hours: 
Max. Marks: 
Unit I: 
  • Chromosomes: Morphology, Chromonema, Chromomeres, telomeres, Primary & secondary constrictions, Chromatids
  • Chromosome type- Polytene & Lampbrush
  • Chromosomal Organization: euchromatin, Heterochromatin ,  nucleosome concept


Unit II: 
  • DNA structure(A, B, Z type)
  • Experiments of Messelson & Stahl
  • Replication(Semi-conservative mechanism) of prokaryotes with reference to polymerases
  • Topoisomerases, Single stranded binding protein, Replication forks(Unidirectional & Bidirectional), Leading & lagging strand, RNA primers & Okazaki fragments


Unit III: 
  • RNA structure & types( mRNA, rRNA, tRNA)
  •  Transcription of prokaryotes
  •  (Idea about Polymerases)
  • Translation – Basic idea about  Protein synthesis in prokaryotes
  • Genetic code


Unit IV: 
  • Determination of Sex – Chromosomal mechanism & environmental influence, the sexual function of X &Y chromosome, Gyandromorphs, Genic Balance Theory
  • Sex linked inheritance in man & Drosophila, Y linked genes, Sex limited genes, Sex influenced genes
Unit V: 
  • Mutations- Chromosomal aberrations, Gene mutations
  • Human genetics- Chromosomal & single gene disorder, Genetics counseling, Amniocentesis
  • Eugenics & Euthenics
Essential Readings: 
  • Genetics; Winchester, A.M; Oxford and IBH Publishing Co.
  • Genetics; Strickberger; Macmillan, Prentice Hall of India.
  • Principles of Genetics; Gardener, E,J; Wiley eastern, New Delhi.
  • Primose, S.B. Tyman, R.M. and Old, R.W. Principles of gene manipulation, Willey- Blacwell.
  • Cell and Molecular Biology; Gerald Karp; John Wiley and Sons,inc
  • A Textbook of Genetics; Rastogi, V.B.; Ramnath & Kedarnath.
  • Molecular Biology of the cell; Bruce Alberts, Julian Lewis, James D.Watson; Garland Publishings  
  • Cell and Molecular Biology; Phillip Sheeler,   Donald E. Bianchi; John Wiley and Sons. Becker, W.M., Kleinsmith, L.J., Hardin. J. and Bertoni, G. P. (2009). The World of the Cell. VII Edition. Pearson Benjamin Cummings Publishing, San
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts,
  • Peter Walter: Molecular Biology of the Cell, IV Edition.
  • Cooper G. M. and Robert E. Hausman R. E. The Cell: A Molecular Approach, V Edition, ASM Press and Sinauer Associates.
  • De Robertis, E.D.P. and De Robertis, E.M.F. (2006). Cell and Molecular Biology. VIII Edition. Lippincott Williams and Wilkins, Philadelphia.
  • Karp, G. (2010) Cell and Molecular Biology: Concepts and Experiments. VI Edition. John Wiley and Sons. Inc.
  • Lewin B. (2008). Gene XI, Jones and Bartlett
  • McLennan A., Bates A., Turner, P. and White M. (2015). Molecular Biology IV Edition. GS, Taylor and Francis Group, New York and London.
Academic Year: