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Molecular Biology
Paper Code:
ZOL-213
Credits:
3
Contact Hours:
45.00
Max. Marks:
100.00
9.00
Unit I:
UNIT I
Chromosomes: Morphology, Chromonema, Chromomeres, Telomeres, Primary & secondary constrictions, Chromatids
Chromosome type- Polytene & Lampbrush
Chromosomal Organization: Euchromatin, Heterochromatin , Nucleosome concept
7.00
Unit II:
UNIT II
Nucleosides, Nucleotides
DNA, RNA
Mobile DNA
DNA structure(A, B, Z type)
Experiments of Messelson & Stahl
10.00
Unit III:
UNIT III
Replication(Semi-conservative mechanism)
Elementary idea about Polymerases,Topoisomerases, Single stranded binding protein, Replication forks(Unidirectional & Bidirectional), Leading & lagging strand, RNA primers & Okazaki fragments
10.00
Unit IV:
UNIT IV
RNA structure & types( mRNA, rRNA, tRNA)
Prokaryotic and Eukaryotic Transcription: RNA Polymerases, Transcription factors.
Transcription termination
Mechanism of transcription
Post Transcriptional modification in RNA
9.00
Unit V:
UNIT V
Translation
Genetic Code
Prokaryotic and Eukaryotic translation
Translational Machinery
Translational Initiation, Elongation and termination
Co and post translational modification
Essential Readings:
Molecular Biology of the gene; Watson J.D.; Benzamin/ Cummings.
Molecular Biology of the Cell (2nd Edition) B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, and J.D. Watson, Garland publishing. Inc., New York, 1994.
Molecular Cell biology (2nd Edition) J. Darnell, H. Lodish and D.Baltimore, Scientific American Books,USA,1994.
Cell & Molecular Biology, (8th edition), E D P Roberties & E M F Roberties, Lippincott Williams & Wilkins, 2005
The cell, (5th edition), R C Swanson and P C Webster , Prentice hall of India Pvt. Ltd., 1990
Cell and Molecular Biology, (3rd edition), P Sheeler and D E Bianchi, John Wiley & Sons, Inc, 1987
Cell and Molecular Biology: Concepts and Experiments, (4th edition), G Karp, John Wiley & sons, Inc., 2005
The cell. A Molecular Approach, (4th edition), G H Cooper and R E Hausman, ASM Press, 2007
Gene VII, Indian eds. Lewin, B. Oxford university press, Bombay
Academic Year:
