IMMUNOLOGY

Paper Code: 
24DZOL515A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
Course objectives: 
This course will enable the students to – 
1. Appraise the detailed knowledge of our immune system to defend against invading  pathogens in a logical fashion.  
2. Differentiate and evaluate between innate and acquired immunity; Humoral and cell  mediated immunity and the consequences of its failure like autoimmunity,  hypersensitivity and immunodeficiencies. 
3. Develop an understanding about the role of effector cells and molecules of the immune  system as complements and antibodies. 
 
Course Outcomes: 

Course

Learning outcomes

(at course level)

Learning and 

teaching strategies

Assessment

Strategies

Course Code

Course Title

24DZOL 515A

Immunology

THEORY

 

CO:121 Distinguish primary and secondary lymphoid organs and various cells  of the Immune system and differentiate between immunogens and antigens.

CO:122 Distinguish the  major cellular and 

tissue components  which comprise the  innate and adaptive  immune

system. compare and  contrast between systemic and organ specific autoimmune disease and judge the role of vaccines in artificial and natural immunity.

CO:123 Examine & 

interpret various forms  of antibody-antigen interactions and correlate the structure of different classes of antibodies with their effector functions.

CO:124 Evaluate the role of MHC in self restriction and could differentiate between endogenous and exogenous antigen presentation and develop the understanding about the centralized role of cytokines in immunity.

CO:125 Summarize the role of complements in innate and adaptive immunity and could assess the various kinds of hypersensitive reactions and their consequences.

CO:126 Contribute effectively in course-specific interaction

The approach in  teaching:

Interactive 

Lectures, 

Discussion, 

Tutorials, 

Demonstration

 

Learning 

activities for the  students:

Self-learning 

assignments, 

Effective 

questions, 

Simulation, 

Seminar 

 

 

Assessment 

Strategies

Class test, Semester  end examinations,  Quiz, Solving  problems in tutorials,  Assignments, 

Presentation.

 

12.00
Unit I: 
Overview of Immune System & Antigens
Historical perspective of Immunology, 
Early theories of Immunology, 
Cells and organs of the Immune system 
Antigenicity and immunogenicity, Immunogens,
Adjuvants and haptens, 
Factors influencing immunogenicity 
B and T-Cell epitopes 
 
12.00
Unit II: 
Innate and Adaptive Immunity
Innate immunity-Anatomical barriers, Inflammation, Cell and molecules involved in innate immunity 
Adaptive immunity-Cell mediated and humoral immunity 
Immune dysfunctions (brief account of autoimmunity with reference to Rheumatoid Arthritis and tolerance, AIDS). 
Passive: Artificial and natural Immunity, Active: Artificial and natural Immunity, Vaccines and its types 
 
12.00
Unit III: 
Immunoglobulins
Structure and functions of different classes of immunoglobulins, 
Antibody mediated effector functions 
Antigen antibody interactions, Immunoassays (ELISA and RIA), Polyclonal sera, Hybridoma technology: Monoclonal antibodies in therapeutics and diagnosis 
 
12.00
Unit IV: 
Major Histocompatibility Complex & Cytokines
Structure and functions of MHC molecules. 
Endogenous and exogenous pathways of antigen processing and presentation Properties and functions of cytokines, Therapeutics Cytokines 
 
12.00
Unit V: 
Complement System & Hypersensitivity
Components and pathways of complement activation. 
Gell and Coombs‘ classification and brief description of various types of hypersensitivities 
 
Essential Readings: 
ESSENTIAL READINGS: 
● Roitt‘s essential Immunology, P. Delves, et al., 11th ed., Blackwell Publishing, 2006
● Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006). Immunology, VI Edition. W.H. Freeman and Company. 
 
SUGGESTED READINGS: 
● David, M., Jonathan, B., David, R. B. and Ivan R. (2006). Immunology,VII Edition, Mosby, Elsevier Publication. 
● Abbas, K. Abul and Lechtman H. Andrew (2017) Cellular and Molecular Immunology. V Edition. Elsevier; 9th edition 
 
e-RESOURCES: 
∙ Immunology- ePG pathshala- Inflibnet centre- 
 
e-JOURNAL: 
● Immunology- Wiley online Library- ISSN 1365-2567 
● Scandinavian Journal of Immunology-Online ISSN: 1365-3083
 
Academic Year: