Immunology

Paper Code: 
ZOL 512
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to -

  • Appraise Primary and Secondary organs of the Immune system.
  • Analyze antibody-antigen interaction, autoimmune diseases, the concept of antigen, antigenic determinants, hapten, factors affecting antigenicity
  • Critique the structure, types, and functions of Immunoglobulin
  • Relate the functioning of CD4 and CD8 T cells and B cells in immune responses.
  • Acquainted with how the immune system distinguishes self from non-self.

 

Course Outcomes (COs): 

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment 

Strategies

Paper Code

Paper Title

ZOL 512

Immunology

Students will 

CO 86: Distinguish primary and secondary organs of the Immune system.

CO 87: Examine antibody-antigen interaction, autoimmune diseases, the concept of antigen, antigenic determinants, hapten, factors affecting antigenicity

CO 88: Investigate the structure, types and functions of Immunoglobulin, 

CO 89: Scrutinize the major cellular and tissue components which comprise the innate and adaptive immune system.  Understand how immune responses by CD4 and CD8 T cells, and B cells are initiated and regulated. 

The approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, PowerPoint presentations, Explanation by videos

Learning activities for the students:

Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

Class test 

Semester end examinations,

Quiz, 

Assignments, 

Presentation

Surprise test

Open book test

 

7.00
Unit I: 
UNIT I

Immunology

  • Definition
  • Types of immunity: innate and acquired
  • Antigen: Antigenicity of molecules,Immunogenicity and its properties, haptens, adjuvants

 

8.00
Unit II: 
UNIT II
  • Antibody
  • Definition.
  • Structure , effector function
  • (IgG. IgM. IgD. IgA and IgE)
  • Properties and function of each class of immunoglobulin.
  • Isotype, Allotype, Ideotype
  • Antigen-antibody reactions
  • Precipitation reaction
  • Agglutination reaction

 

10.00
Unit III: 
UNIT III
  • Cells  and organs of Immunity
  • Primary and Secondary lymphoid organs
  • Dendritic cells
  • Macrophages.
  • Lymphocytes (B- and T- types). T.- Helper cells. T-killer cells, plasma cells and memory cells

 

12.00
Unit IV: 
UNIT IV
  • MHC genes and gene products.
  • Mechanism of Humoral& Cell mediated  immune response
  • Complement and its action
 

 

8.00
Unit V: 
UNIT V
  • Autoimmunity : Hashimoto thyroiditis, Myasthenia gravis, Rheumatoid arthritis, Lupus
  • Immunodeficiency: AIDS- causes, symptoms, treatment, mode of infection, HIV lifecycle
  • Hypersensitivity-  Type I to IV
  • Cvtokines:  Types, Properties and Function.
Essential Readings: 
  • Kuby, Immunology, W.H. Freeman and Company.
  • D.M. Wear, Immunology ELBS (English) Language Book Society Low  Priced edition, Longman Singapore Publishers Ltd.
  • Iyan M. Roitt Essential Immunology EIBS Low Priced Edition Black
  • Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006).  Immunology, VI  Edition. W.H. Freeman and Company.
  • David, M., Jonathan, B., David, R. B. and Ivan R. (2006).  Immunology,VII Edition, Mosby, Elsevier Publication.
  • Abbas, K. Abul and Lechtman H. Andrew (2003.) Cellular and Molecular  Immunology. V Edition. Saunders Publication.

 

Academic Year: 
2021-2022
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