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HUMAN GENETICS II
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Course |
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Course Code |
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HUMAN GENETICS II (Theory)
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CO175. Analyze genetic |
Approach in |
Class test |
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variation, chromosome |
teaching: |
Semester end |
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rearrangement and |
Interactive Lectures, |
examinations, |
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aberrations. |
Discussion, |
Quiz |
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CO176. Develop an |
Tutorials, Reading |
Assignments, |
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understanding of the |
assignments, |
Presentations |
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Immunogenetics |
Demonstration, |
Surprise test |
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CO177. Analyze and |
Team teaching |
Open book |
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understand extranuclear |
Learning activities |
test |
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genetics, stem cells and |
for the students: |
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24ZOL |
cloning |
Self-learning |
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423 D |
CO178. Evaluate and |
assignments, |
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implement Human |
Effective questions, |
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Genome Project, and |
Simulation, Seminar |
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Genetic mapping |
presentation, Giving |
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CO179. List genetic |
tasks, Field practical |
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counseling, Genomic |
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testing and eugenics |
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CO180. Contribute |
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effectively in course- |
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specific interaction |
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- Genetic variation – History, Categories of mutations, chromosome and gene mutations, Extrachromosomal mutations, Mutator genes, Mobile genetic elements, Induced mutations, Physical and chemical mutagens, Molecular basis of spontaneous and induced mutations, DNA repair mechanisms, Reversion, Transposon mutagenesis, In vitro mutagenesis, Environmental mutagenesis
- Chromosome rearrangements and Cancer. Chromosomal aberration :
- Numerical : Aneuploidy, Polyploidy
- Structural : Translocation, Duplication, Inversion, Ring Chromosome and Deletion
- Others : Mosaic, Chimera [Individual with two cell lines]
- Immunogenetics -
- Genetics of normal immune system. Inherited immunodeficiency, eg. X-linked
- Agammaglobulinaemia. Major Histocompatibility Complex – Study of Twins (MHC), HLA disease associations.
- Transplantation, graft –versus-host disease. Pharmacogenetic – Definition, gene loci influencing drug metabolism and pharmacogenetic interactions.
● Extranuclear genetics-Role of organellar genome, maternal inheritance and maternal effect.
●Stemcellresearchand
● Source and isolation of stem cells ,Use of stem cells in human welfare ,Making stem cell lines :Methodology
Whole body cloning ,Organ Cloning
- Human Genome Project
- History, Organization and goals of Human Genome Project Human Genome Project : Friend and Foe ,Repetitive DNA in human genome –Alu and SINE repeats Human genome mapping- Physical, Genetic and Microsatellite mapping,
- Genetic counseling
- Components of genetic counseling, Legal and ethical considerations
- risk assessment and counseling in common Mendelian and multifactor syndromes;
- Genetic testing: biochemical & molecular tests: in children, Presymptomatic testing for late onset diseases (predictive medicine); Prenatal and Preimplantation screening and diagnosis: Indications for prenatal diagnosis, Indications for chromosomal testing,
- Noninvasive methods (Ultrasound, Embryoscopy, MRI, etc.); Invasive methods; Prenatal screening for Down’s syndrome (maternal serum) & Neural tube defect; Pre implantation genetic diagnosis; Ethical issues in prenatal screening & diagnosis.
- Study of Eugenics
- Negative Eugenics
- Positive Eugenics
- Snustad& Simmons, Principles of Genetics, 4th Edition, Wiley,2005.
- Hartl and Jones, Genetics-Principles and Analysis, 4th Edition, Jones &Bartlett,1998.
- Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland2007.
- Lewin, Genes IX, 9th Edition , Jones & Bartlett,2007.
- Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald,2005.
- Mange and Mange, Basic Human Genetics, 2nd Edition, SinauerAssoc,1999.
- Vogel and Motulsky, Human Genetics, 3rd Edition, Springer Verlag,1997.
- Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci.Publishing, 2004.
