Coming soon
HUMAN GENETICS- II
OBJECTIVES- The course Objectives to provide students with a detailed knowledge of:
- Organization of the human genome; Genes and chromosome structure,
function and inheritance - Genetic variation
- Immunogenetics
- Extranuclear genetics
- Human Genome Project
- Genetic counseling
|
Genetic variation – History, Categories of mutations, chromosome and gene mutations, Extrachromosomal mutations, Mutator genes, Mobile genetic elements, Induced mutations, Physical and chemical mutagenes, Molecular basis of spontaneous and induced mutations, DNA repair mechanisms, Reversion, Transposon mutagenesis, In vitro mutagenesis, Environmental mutagenesis Chromosomal aberration : Numerical : Aneuploidy, Polyploidy Structural : Translocation, Duplication, Inversion, Ring Chromosome and Deletion |
Others : Mosaic, Chimera [Individual with two cell lines]
|
Immunogenetics - Genetics of normal immune system. Inherited immunodeficiency, eg. X-linked agammaglobulinaemia. Major Histocompatibility Complex – Study of Twins (MHC), HLA disease associations. Tranplantation, graft –versus-host disease. |
Pharmacogenetic – Definition, gene loci influencing drug metabolism and pharmacogenetic interactions.
|
Extranuclear genetics-Role of organellar genome, maternal inheritance and maternal effect. Stem cell research and cloning |
Source and isolation of stem cells ,Use of stem cells in human welfare ,Making stem cell lines :Methodology ,Whole body cloning ,Organ Cloning
|
Human Genome Project History, Organization and goals of Human Genome Project Human Genome Project : Friend and Foe ,Repetitive DNA in human genome –Alu and SINE repeats Human genome mapping- Physical, Genetic and Microsatellite mapping, |
|
Genetic counseling Components of genetic counseling, Legal and ethical considerations risk assessment and counseling in common Mendelian and multifactor syndromes; Genetic testing: biochemical & molecular tests: in children, Presymptomatic testing for late onset diseases (predictive medicine); Prenatal and Preimplantation screening and diagnosis: Indications for prenatal diagnosis, Indications for chromosomal testing, Noninvasive methods (Ultrasound, Embryoscopy, MRI, etc.); Invasive methods; Prenatal screening for Down’s syndrome (maternal serum) & Neural tube defect; Pre-implantation genetic diagnosis; Ethical issues in pre-natal screening & diagnosis. Study of Eugenics
|
Positive Eugenics
- Snustad& Simmons, Principles of Genetics, 4th Edition, Wiley, 2005.
- Hartl and Jones, Genetics-Principles and Analysis, 4th Edition, Jones & Bartlett, 1998.
- Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland 2007.
- Lewin, Genes IX, 9th Edition , Jones & Bartlett, 2007.
- Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald, 2005.
- Mange and Mange, Basic Human Genetics, 2nd Edition, SinauerAssoc, 1999.
- Vogel and Motulsky, Human Genetics, 3rd Edition, Springer Verlag, 1997.
- Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci. Publishing, 2004.
- How1ey and Mori, The Human Genome, Academic Press, 1999.
- Advanced Molecular Biology Twiman
- Molecular Cloning Part- 1 Manniatis
- Molecular Cloning Part - 2 Manniatis
- Molecular Cloning Part - 3 Manniatis
- Structural Chemistry and Molecular Biology :Alexander Rich and Norman Davidson
- The Chemical Foundations of Molecular James D. Watson
- Biology of the Gene (2nd ed.) Molecular Biology of the Cell :Lewis and Watson
- Recombinant DNA :Witkowski
- Genes VI :Benjamin Lewin
- Principles of gene Manipulation : R. W. Old and Primrose
- Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N. Davidson
- Genes VII :Benjamin Lewin
- Human Genetics: Concepts and Applications by Lewis R (2001) McGrawHi; Boston.
- Basic Human Genetics by E.J. Manage and A.P. Manage (1997 India Reprint) Rastogi Publications, Meerut.
- Mendelian inheritance in Man: Catalogs of Autosomal recessive, and x-linked phenotypes.[12th editions –1998 ] byMcKusick, V.A. Johns Hopkins university press, Baltimore.
