Course objectives:
This course will enable the students to -
Course Outcomes (COs):
Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
|
Paper Code |
Paper Title |
|||
ZOL 323D |
Human Genetics- I
|
The course Objectives to provide students with a detailed knowledge of: CO63: Organization of the human genome; Genes and chromosome structure, CO64: Genetic disorders related to metabolism CO65: Sex Determination CO66: Techniques in the study of chromosomes and applications |
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Guest lectures
Learning activities for the students: Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical
|
Class test Semester end examinations, Viva |
Introduction to Human Genetics
Introduction to Human Genetics
Genetic basis of eye disorders: Colour Blindness, Retinitis pigmentosa, Huntington’s disease
Chromosomal basis of Genetics disorders: Down Syndrome, Patau and Edward Syndrome ,Turner Syndrome ,Klinefelter Syndrome ,Cri-du Chat Syndrome
Sex Determination
Special types of chromosome-sex chromosomes, sex chromatin, B-chromosome, polytene and lampbrush chromosomes; Numerical and structural changes in the chromosome.
Sex-linked inheritance- X-linked recessive, dominant; Y–linked; Sex-limited and sex-influenced traits
Dosage compensation;
Repetitive DNA-satellite
DNAs and interspersed repeated DNAs
Suggested Readings:
Nelson et al, Lehninger’s Principles of Biochemistry, 4th Edition, McMillan, 2006.
Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland 2007.
Lewin, Genes IX, 9th Edition , Jones & Bartlett, 2007.
Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald, 2005..
Lewis, Human Genetics, 7th Edition, WCB & McGraw, 2007..
Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci. Publishing, 2004.
Structural Chemistry and Molecular Biology Alexander Rich and Norman Davidson
The Chemical Foundations of Molecular :James D. Watson
Biology of the Gene (2nd ed.)
Molecular Biology of the Cell ; Lewis and Watson
Genes VI : Benjamin Lewin
Human Cytogenetic Techniques and Clinical Applications HemaPurandare and ArnitChakravarty
Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N. Davidson
Essentials of Human Genetics Bhatnagar,Kothari,Mehta
Genes VII :Benjamin Lewin
Molecular Biology of the Gene (4th ed.) Watson
Molecular Biology of the Cell :Alberts. Lewis & Watson
An introduction to genetic Engineering Desmond S. T. Nicoll
Principles and Practive of Medical Genetics, by Emery, A.E.H and D.L. Rimoin (Eds_ (1990-2nd edition) Churchill Livingstone, Edinburgh.
Molecular Basis of Inherited Diseases, (6th Edition-1989) by Scriver, C.R. A.L. Beudit, W.S. Sty abnd D. Valle (Eds0 McGrawHill, New York.
Human Genetics by S.D. Gangane (2nd edition-Reprint 2001), B.L Churchill Livingstone Pvt. Ltd., New Delhi.
Genetics in Medicine by M.W. Thompson et al, 5th Edition, W.B. Sounders Company, London
Genetic basis of common diseases by R. A. King et al, Oxford University Press.
Mendelian inheritance in Man by Mc. Kusick V.A. (1998), 12th Edition, John Hopsins University Press, Baltimore.
Suggested Readings: