Genetics II

Paper Code: 
ZOL 423D
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to –

  1. Develop an understanding about organization of the human genome; Genes and chromosome structure, function and inheritance, Genetic variation, Immunogenetics, Extranuclear genetics, Human Genome Project, Genetic counselling

 

Course Outcomes (COs):

Course

Learning outcomes

(At course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL

 423 D

 

Genetics- II

Students will:

CO146: Develop an understanding  of the human genome; Genes and chromosome structure,
function and inheritance

CO147: Analyse genetic variation, Immunogenetics, Extranuclear genetics

CO148: Analyse and understand  Human Genome Project, Genetic counselling

CO 149: Evaluate and implement Genomic data base 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

Class test

Semester end examinations,

Quiz

Assignments,

Presentations

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I
  • Genetic variation – History, Categories of mutations, chromosome and gene mutations, Extrachromosomal mutations, Mutator genes, Mobile genetic elements, Induced mutations, Physical and chemical muta genes, Molecular basis of spontaneous and induced mutations, DNA repair mechanisms, Reversion, Transposon mutagenesis, In vitro mutagenesis, Environmental mutagenesis
  • Chromosome rearrangements and Cancer. Chromosomal aberration :
  • Numerical : Aneuploidy, Polyploidy
  • Structural : Translocation, Duplication, Inversion, Ring Chromosome and Deletion
  • Others : Mosaic, Chimera [Individual with two cell lines]

 

12.00
Unit II: 
UNIT II
● Immunogenetics -
● Genetics of normal immune system. Inherited immunodeficiency, eg. X-linked
● Agammaglobulinaemia. Major Histocompatibility Complex – Study of Twins (MHC), HLA disease associations.
● Tran plantation, graft –versus-host disease. Pharmacogenetic – Definition, gene loci influencing drug metabolism and pharmacogenetic interactions
 
12.00
Unit III: 
UNIT III
  • Extranuclear genetics-Role of organellar genome, maternal inheritance and maternal effect.
  • Stem cell research and cloning
  • Source and isolation of stem cells ,Use of stem cells in human welfare ,Making stem cell lines :Methodology
  • Whole body cloning ,Organ Cloning

 

12.00
Unit IV: 
UNIT IV
  • Human Genome Project
  • History, Organization and goals of Human Genome Project Human Genome Project : Friend and Foe ,Repetitive DNA in human genome –Alu and SINE repeats Human genome mapping- Physical, Genetic and Microsatellite mapping,

 

12.00
Unit V: 
UNIT V
  • Genetic counseling
  • Components of genetic counseling, Legal and ethical considerations
  • risk assessment and counseling in common Mendelian and multifactor syndromes;
  • Genetic testing: biochemical & molecular tests: in children, Presymptomatic testing for late onset diseases (predictive medicine); Prenatal and Preimplantation screening and diagnosis: Indications for prenatal diagnosis, Indications for chromosomal testing,
  • Noninvasive methods (Ultrasound, Embryoscopy, MRI, etc.); Invasive methods; Prenatal screening for Down’s syndrome (maternal serum) & Neural tube defect; Pre- implantation genetic diagnosis; Ethical issues in prenatal screening & diagnosis.
  • Study of Eugenics
    • Negative Eugenics
    • Positive Eugenics

 

Essential Readings: 
  • Snustad& Simmons, Principles of Genetics, 4th Edition, Wiley,2005.
  • Hartl and Jones, Genetics-Principles and Analysis, 4th Edition, Jones & Bartlett,1998.
  • Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland2007.
  • Lewin, Genes IX, 9th Edition , Jones & Bartlett,2007.
  • Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald,2005.
  • Mange and Mange, Basic Human Genetics, 2nd Edition, SinauerAssoc,1999.
  • Vogel and Motulsky, Human Genetics, 3rd Edition, Springer Verlag,1997.
  • Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci.Publishing, 2004.

 

References: 

SUGGESTED READINGS:

  • How1ey and Mori, The Human Genome, Academic Press,1999.
  • Advanced Molecular Biology Twiman
  • Molecular Cloning Part- 1 Maniatis
  • Molecular Cloning Part - 2 Maniatis
  • Molecular Cloning Part - 3 Maniatis
  • Structural Chemistry and Molecular Biology :Alexander Rich and NormanDavidson
  • The Chemical Foundations of Molecular James D.Watson
  • Biology of the Gene (2nd ed.) Molecular Biology of the Cell :Lewis andWatson
  • Recombinant DNA:Witkowski
  • Genes VI :BenjaminLewin
  • Principles of gene Manipulation : R. W. Old andPrimrose
  • Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N.Davidson
  • Genes VII :BenjaminLewin
  • Human Genetics: Concepts and Applications by Lewis R (2001) McGrawHi;Boston.
  • Basic Human Genetics by E.J. Manage and A.P. Manage (1997 India Reprint)Rastogi Publications,Meerut.
  • Mendelian inheritance in Man: Catalogs of Autosomal recessive, and x-linked phenotypes.[12th editions –1998 ] byMcKusick, V.A. Johns Hopkins university press, Baltimore.

 

Academic Year: 
2022-2023
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