Coming soon
Genetics and Biostatistics
Paper Code:
ZOL-214
Credits:
3
Contact Hours:
45.00
Max. Marks:
100.00
Objective:
Course objectives:
This course will enable the students to –
1. Analyze the patterns of Mendelian inheritance and Interactions of Genes and their expressions.
2. Appraise role of crossing over and linkage in heredity
3. Examine cytoplasmic inheritance and its importance.
4. Implement the role of genetics in human welfare and genetic counseling.
5. Test how natural polymorphism and genetic variation can give rise to mutant genes, and how these genetic errors are inherited;
6. Execute the scope and application of Biostatistics and Use of data analysis methods.
Course Outcomes (COs):
Course objectives:
This course will enable the students to –
1. Analyze the patterns of Mendelian inheritance and Interactions of Genes and their expressions.
2. Appraise role of crossing over and linkage in heredity
3. Examine cytoplasmic inheritance and its importance.
4. Implement the role of genetics in human welfare and genetic counseling.
5. Test how natural polymorphism and genetic variation can give rise to mutant genes, and how these genetic errors are inherited;
6. Execute the scope and application of Biostatistics and Use of data analysis methods.
Course Outcomes (COs):
9.00
Unit I:
UNIT I:
● Mendelian inheritance patterns & laws of heredity
● Co and incomplete dominance
● Interactions of Genes- Supplementary, Complementary, Duplicate, Epistasis(dominant &recessive)
● Multiple alleles-Coat colour in rabbit, Human blood group-ABO & Rh
● Gene expression- Lethal genes, Pleiotropic genes
● Multiple genes- Seed coat in wheat, skin colour in human
7.00
Unit II:
UNIT II:
● Linkage & construction of linkage maps
● Crossing over- Mechanism, theories, Cytological detection & significance
● Cytoplasmic inheritance
● Human genetics- Chromosomal & single gene disorder, Genetics counseling, Amniocentesis
● Eugenics & Euthenics
10.00
Unit III:
UNIT III:
● Determination of Sex – Chromosomal mechanism & environmental influence, the sexual function of X &Y chromosome, Gyandromorphs, Genic Balance Theory,
● Sex linked inheritance in man & Drosophila, Y linked genes, Sex limited genes, Sex influenced genes
● Mutations- Chromosomal aberrations, Gene mutations
10.00
Unit IV:
UNIT IV:
● Introduction, scope and application of Biostatistics
● Frequency distribution
● Graphical presentation of data (bar diagram, frequency polygon, histogram, pie chart)
9.00
Unit V:
UNIT V:
● Mean. mode, median and their significance
● Standard deviation,variance and coefficient of variance
● Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)
Essential Readings:
● Genetics; Winchester, A.M; Oxford and IBH Publishing Co.
● Genetics; Strickberger; Macmillan, Prentice Hall of India.
● Principles of Genetics; Gardener, E,J; Wiley eastern, New Delhi.
● Primose, S.B. Tyman, R.M. and Old, R.W. Principles of gene manipulation, Willey Blacwell.
● Cell and Molecular Biology; Gerald Karcp; John Wiley and Sons,inc
Bencroft, H. Introduction to Biostatistics Harper and Row. New York, 1957.
● Bailey, N.T.J. Statistical method in Biology Low Priced Text Book English Language Society, London, 1959.
● Bishop O.N. Statistics for biology, Prentice Hall Press
References:
SUGGESTIVE READINGS:
● A Textbook of Genetics; Rastogi, V.B.; Ramnath &Kedarnath.
● Genetics: Gupta P.k.; Rastogi publication.
● Cell and Molecular Biology; Phillip Sheeler, Donald E. Bianchi; John Wiley and Sons.
● Biostatistics; Gupta, S.P.;Sultan Chand &Co.
● Molecular Biology of the cell; Bruce Alberts, Julian Lewis, James D.Watson; Garland Publishings
● Mahajan B.K., Methods in Biostatistics, Jaypee Brothers.
e- RESOURCES
JOURNALS:
• Journal of Genetics ISSN: 0022-1333 (print); 0973-7731 (web)
Academic Year:
