ENVIRONMENTAL TOXICOLOGY I

Paper Code: 
ZOL 323 C
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to -

  1. To provide students with a detailed  understanding of different branches of toxicology
  2. To create awareness about toxicants present in the nature and their effect on environment and living organisms.

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 323C

Environmental Toxicology I

 

CO61: The course objective is to provide students with a detailed  understanding of different branches of toxicology

CO62:  Toxicant present in the nature and their effect on environment and living organisms

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

 

Learning activities for the students:

Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

 

Class test

Semester end examinations,

Viva

 

 

10.00
Unit I: 
UNIT I

History and Scope of Toxicology

Principles of Toxicology

  •     Different Areas of Toxicology
  •     Classification of Toxic Agent
  •     Spectrum of Undesired Effects

Interaction of Chemicals

  •     Additive
  •     Synergistics
  •     Potentiation
  •     Antagonism

Dose Response

  •     Individual or Graded
  •     Response Relationships
  •     Quantal Dose
  •     Dose Response Curves

Variation in Toxic Responses

  •     Selective Toxicity
  •     Species Differences
  •     Individual Differences

Animal Toxicity Tests

  •     Acute
  •     Subacute
  •     Subchronic
  •     Chronic
  •     Development and Reproductive Toxicology
  •     Mutagenicity
  •     Skin and Eye Irritation
     
15.00
Unit II: 
UNIT II

Mechanisms of Toxicity

  •     Delivery
  •     Absorption
  •     Distribution
  •     Excretion
  •     Cellular Dysfunctions and resultant toxicities
  •     Repair or Dysrepair

Biotransformation of Xenobiotics

  •     Phase I Enzymes (Hydrolysis, Reduction, Oxidation
  •     Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acelylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation)

Risk Assessment

  •     Hazard Identifications (Assessing Toxicity of Chemicals)
  •     Risk Characterization
  •     Risk Perception & comparative Analysis of Risk
  •     Environmental Impact Assessment
10.00
Unit III: 
UNIT III

Specific Responses of Toxicity

  •     Carcionogenesis
  •     Mutagenecity (Genetic Toxicology)
  •     Teratogenecity (Development Toxicity)
15.00
Unit IV: 
UNIT IV

Target Organ Toxicity

  •     Liver
  •     Kidney
  •     Nervous System
  •     Blood
10.00
Unit V: 
UNIT V

Physicochemical nature & Effect of Toxic Agents

  •     Pesticides: (General account )Organochlorine Compound, Antocholinesterase agents and pyrethroids esters
  •     Metals (Arsenic,Lead, Mercury)
  •     Industrial Solvents(General account)
  •     Radiation & Radioactive materials
Academic Year: 
2020-2021
  • Printer-friendly version
  • PDF version