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Environmental Toxicology I
Paper Code:
ZOL-323(C)
Credits:
4
Contact Hours:
60.00
Max. Marks:
100.00
Objective:
OBJECTIVES- The course objective is to provide students with a detailed understanding of:
- Different branches of toxicology
- Toxicant present in the nature
- Their effect on environment and living organisms
10.00
Unit I:
UNIT I
History and Scope of Toxicology
Principles of Toxicology
- Different Areas of Toxicology
- Classification of Toxic Agent
- Spectrum of Undesired Effects
Interaction of Chemicals
- Additive
- Synergistics
- Potentiation
- Antagonism
Dose Response
- Individual or Graded
- Response Relationships
- Quantal Dose
- Dose Response Curves
Variation in Toxic Responses
- Selective Toxicity
- Species Differences
- Individual Differences
Animal Toxicity Tests
- Acute
- Subacute
- Subchronic
- Chronic
- Development and Reproductive Toxicology
- Mutagenicity
Skin and Eye Irritation
15.00
Unit II:
UNIT II
Mechanisms of Toxicity
- Delivery
- Absorption
- Distribution
- Excretion
- Cellular Dysfunctions and resultant toxicities
- Repair or Dysrepair
Biotransformation of Xenobiotics
- Phase I Enzymes (Hydrolysis, Reduction, Oxidation
- Phase II Enzyme Reactions (Glucuronidation, Sulfation, Methylation, Acelylation, Amino-acid conjugation Glutathione Conjugation, Phosphorylation)
Risk Assessment
- Hazard Identifications (Assessing Toxicity of Chemicals)
- Risk Characterization
- Risk Perception & comparative Analysis of Risk
Environmental Impact Assessment
10.00
Unit III:
UNIT III
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Specific Responses of Toxicity
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15.00
Unit IV:
UNIT IV
Target Organ Toxicity
- Liver
- Kidney
- Nervous System
- Blood
10.00
Unit V:
UNIT V
Physicochemical nature & Effect of Toxic Agents
- Pesticides: (General account )Organochlorine Compound, Antocholinesterase agents and pyrethroids esters
- Metals (Arsenic,Lead, Mercury)
- Industrial Solvents(General account)
Radiation & Radioactive materials
Academic Year:
