CELL BIOLOGY

Paper Code: 
ZOL 122
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to -

  1. The course provides detailed insight into basic concepts of cellular structure and function covering all the components of prokaryotic and eukaryotic cells, especially macromolecules, membranes, and organelles.
  2. It also gives an account of the complex regulatory mechanisms that control cell functions therefore it will help students to  understand how these cellular components are used to generate and utilize energy in cells.

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 122

 

Cell Biology

The students will be able to:

CO5: Differentiate between prokaryotic and eukaryotic cells and their cellular organelles.

CO6: Understand the detailed structure of biomembrane and its role in the mechanism of active and passive transport.

CO7: Develop an understanding of the role of different cytoskeleton components in intracellular movements and intercellular interactions.

CO8: Acquire the detailed knowledge of different pathways related to cell signaling and apoptosis thus enabling them to understand the importance of cell cycle regulation checkpoints.

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, PowerPoint presentations

 

Learning activities for the students:

Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks.

Class test

Semester end examinations,

 Quiz,

Assignments,

Presentation

Open book test

 

9.00
Unit I: 
UNIT I

Cell Theory

Structure of prokaryotic and eukaryotic cells.

Bio-membranes

  •     Molecular composition and function
  •     Transport across cell membrane: diffusion, active transport and pumps.
  •     Co-transport by symporters or antiporters
9.00
Unit II: 
UNIT II

Cytoskeleton

  •         Microfilaments, Intermediate  filaments and Microtubules-  structure and dynamics
  •         Cell movements-Intracellular transport, role of kinesin and dynein
15.00
Unit III: 
UNIT III

Cell –Cell Signaling and Cell Interaction

  •     Introduction
  •     Cell surface receptors(G-Protein coupled receptor, RTK, Cytokine receptor)
  •     Second messenger system(c-AMP, PIP2, calcium)
  •     MAP kinase pathways

Cell junctions

Cell adhesion

15.00
Unit IV: 
UNIT IV

Cell cycle

  •     Cyclin and cyclin dependent kinases
  •     Regulation of CDK – cyclin activity

Chromosomes, Chromatin, and the Nucleosomes

Chromosome sequence and diversity

12.00
Unit V: 
UNIT V

Intracellular protein traffic

    Uptake into ER

    Post translational modifications

    Golgi sorting

Apoptosis

    Definition ,mechanism and significance

Essential Readings: 

Essential Readings

    Molecular Cell Biology, J. Darnell H.Lodish and D. Baltimore Scientific American Books, Inc., USA.

    The cell. A Molecular Approach, (4th edition), G H Cooper and R E Hausman, ASM Press, 2007.

    Molecular and Cell Biology: concepts and experiments, (6th edition) Gerald Karp and Nancy L Pruitt

Suggested Readings

    Cell and Molecular Biology; De Robertis and De Robertis; Saunders College

    Cell Biology;  Powar, C.B.; Himalaya Publications.

    Molecular Biology of the gene; Watson J.D; Benjamin/ Cummings

    Molecular Biology of the Gene. I.D Watson, N.H. Hopkins, J.W. Roberts, J.A. Steiz and AM Weiner The Benjamin/Cummings Pub. Co., Inc., California.

    Gene IV, Benjamin Lewin. Oxford University Press, UK.

    Molecular Biology and Biotechnology. A comprehensive desk reference, R.A.Meyers (Ed.), VCH Publishers, Inc., New York.

Academic Year: 
2020-2021
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