Cell Biology

Paper Code: 
ZOL 122
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

OBJECTIVES-

  1. To  understand  the  structural  architecture and  functions  of  basic  components  of  prokaryotic  and eukaryotic cells and their organelles
  2. To understand the cell theory
  3. To understand the role of membrane in transport of biomolecules across the cell.
  4. Able to identify the three primary components of the cell’s cytoskeleton and how they affect cell shape, function, and movement.
  5. To understand Cell –Cell Signaling and Cell Interaction
  6. To understand Cell junctions and Cell adhesion
  7. To understand the process of cell division in both somatic and germ cell
  8. To understand Chromosome structure  sequence and diversity
  9. To understand Vesicular traffic in the secretory and endocytic pathways (GERL)

LEARNING OUTCOMES- 

  1. Students will understand the structures and purposes of basic components of prokaryotic and eukaryotic cells, especially macromolecules, membranes, and organelles.
  2. Able to describe the function and the composition of the plasma membrane.
  3. Able to explain the principles of the cell theory.
  4.  Able to understand the importance of the nucleus and its components.
  5. Able to identify the three primary components of the cell’s cytoskeleton and how they affect cell shape, function, and movement.
  6. Able to describe Cell –Cell Signaling and Cell Interaction
  7. Able to describe Cell junctions and Cell adhesion
  8. Able to understand the process of cell division.
  9. Able to understand how the endoplasmic reticulum and Golgi apparatus interact with one another and know with which other organelles they are associated.

 

 

9.00
Unit I: 
UNIT I

Cell Theory

Structure of prokaryotic and eukaryotic cells.

Bio-membranes

  • Molecular composition and function
  • Transport across cell membrane: diffusion, active transport and pumps.

Co-transport by symporters or antiporters

9.00
Unit II: 
UNIT II

Cytoskeleton

·     Microfilaments, intermediate  filaments and microtubules-  structure and dynamics

    Cell movements-Intracellular transport, role of kinesin and dynein

 

15.00
Unit III: 
UNIT III

Cell –Cell Signaling and Cell Interaction

·         Introduction

·         Cell surface receptors(G-Protein couple receptor, RTK, Cytokine receptor)

·         Second messenger system(c-AMP, PIP2, calcium)

·         MAP kinase pathways

Cell junctions

Cell adhesion

15.00
Unit IV: 
UNIT IV

Cell cycle

  • Cyclin and cyclin dependent kinases
  • Regulation of CDK – cyclin activity

Chromosomes, Chromatin, and the Nucleosomes

Chromosome sequence and diversity

12.00
Unit V: 
UNIT V

Intracellular protein traffic

  • Uptake into ER
  • Post translational modifications
  • Golgi sorting

Apoptosis

Definition ,mechanism and significance

Essential Readings: 
  • Cell Biology;  Powar, C.B.; Himalaya Publications.
  • Molecular Biology of the gene; Watson J.D; Benzamin/ Cummings
  • Molecular Cell Biology, J. Darnell H.Lodish and D. Baltimore Scientific American Books, Inc., USA.
  •  Molecular Biology Lab Fax, T.A.Brown (Ed.), Bios Scientific Publishers Ltd., Oxford.

 

References: 

ü  Cell and Molecular Biology; De Robertis and De Robertis; Saunders College

ü  Molecular Biology of the Gene. I.D Watson, N.H. Hopkins, J.W. Roberts, J.A. Steiz and AM Weiner The Benjamin/Cummings Pub. Co., Inc., California.

ü  Molecular Biology of the cell. B. Alberts, D.D.Bray, J.Lewis, M.Rafif, K. Roberts and J.D.Watson. Garland Publishing inc., New York.

ü  Gene IV, Benjamin Lewin. Oxford University Press, UK.

ü  Molecular Biology and Biotechnology. A comprehensive desk reference, R.A.Meyers (Ed.), VCH Publishers, Inc., New York.

ü  Molecular Cloning: A Laboratory Manual, J.Sambrook, E.F.Fristsch and T. Maniatis, Cold Spring Harbor Laboratory Press, New York.

Introduction to Practical Molecular Biology, P.D.Dabre, John Wiley& Sons Ltd. New York. 

Academic Year: 
2019-2020
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