Cell Biology

Paper Code: 
ZOL 122
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

 

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 122

 

Cell Biology

The students will-

 

CO6: Analyse the functions of nucleus and extra nuclear organelles and understand the intricate cellular mechanisms involved.

CO7: Appraise the detailed knowledge of different pathways related to cell signalling and apoptosis thus enabling them to understand the anomalies in cancer

CO8:Develop an understanding about how cells work in healthy and diseased states and to give a ‘health forecast’ by analyzing the genetic database and cell information.

CO9: Investigate new avenues of joining research in areas such as genetic engineering of cells, cloning, vaccines development, human fertility programme, organ transplant, etc.

CO10: Develop an understanding how tissues are produced from cells in a normal course and about any malfunction which may lead to benign or malignant tumor.

CO11: Differentiate and evaluate the role of different cytoskeleton components in intracellular movements and intercellular interactions.

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, PowerPoint presentations

 

Learning activities for the students:

Self learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks.

Class test

Semester end examinations,

 Quiz,

Assignments,

Presentation

Open book test

 

9.00
Unit I: 
UNIT I
  • Cell Theory
  • Structure of prokaryotic and eukaryotic cells.
  • Cell organelles-ER, Golgi, Mitochondria, Ribosomes, Peroxisomes
  • Cytoskeleton: Structure, Function and Dynamics of-
    • Microfilaments: Actin and Myosin
    • Microtubule in mitosis. Kinesin and Dynein.
    • Intermediate Filaments

 

9.00
Unit II: 
Unit II

Bio membranes

  • Phospholipids: main lipid constituent.
  • Cytosolic and exoplasmic face of bio membranes.
  • Intrinsic and extrinsic proteins.
  • Glycolipids.
  • Mobility of lipids and integral proteins
  • Fluidity of bio membrane.

Transport across cell membranes.

  • Passive Transport
  • Diffusion & Facilitated Diffusion
  • Osmosis and water channels.
  • Active Transport- pumps, ABC transporters
  • Cotransport by symporters and antiporters

 

15.00
Unit III: 
UNIT III

Cell-Cell Signalling.

  • Endocrine, paracrine, autocrine signalling.
  • Receptor    Proteins-Intracellular Receptors.
  • Cell surface receptors-G-protein coupled receptors, ion channel receptors, tyrosine kinase linked receptors and receptors with intrinsic enzymatic activity.
  • Second messenger system-cAMP, IP3-DAG and MAP kinase pathways.
  • Signal-Mediated transport through Nuclear Pore.
  • Nuclear Pore Complex.
  • Nuclear export signals.
  • Nuclear localization signals

 

 

12.00
Unit IV: 
UNIT IV

Cell Junctions: Occluding, Adherence and communicating junctions

Cell- cell adhesion molecules

  • Selectin
  • Cadherin
  • Integrin
  • Ig Superfamily

Cell matrix adhesion

  • Integrins
  • Collagen
  • Non-collagen components of extracellular matrix

 

15.00
Unit V: 
UNIT V

Protein sorting and transport

  • Protein secretion- Regulative and Secretory Pathways
  • Targeting proteins to Endoplasmic Reticulum
  • Insertion of protein into ER membrane
  • Protein folding and processing in ER
  • Export of proteins from ER
  • cargo selection, coat protein and vesicle budding
  • Post translational modification in Golgi
  • Protein sorting and export from Golgi

 

Essential Readings: 

ESSENTIAL READINGS:

  • IWASA, J., MARSHALL, W. F., & KARP, G. (2016). Karp's cell and molecular biology: concepts and experiments.
  • COOPER, G. M., & HAUSMAN, R. E. (2009). The cell: a molecular approach. Washington, D.C., ASM Press.
  • Nelson et al, Lehninger’s Principles of Biochemistry, 4th Edition, McMillan, 2006.
  • Alberts et al, Molecular Biology of The Cell, 2nd Edition , Garland 2007.
  • Lewin, Genes IX, 9th Edition , Jones & Bartlett, 2007
  • Molecular Biology of the Cell ; Lewis and Watson
  • Genes VII : Benjamin Lewin
  • Lewis, Human Genetics, 7th Edition, WCB & McGraw, 2007.

 

 

SUGGESTED READINGS:

  • Pastemak, An Introduction to Molecular Human Genetics, 2nd Edition, Fritzgarald, 2005.
  • Strachen and Read, Human Molecular Genetics, 3rd Edition, Garland Sci. Publishing, 2004.
  • Structural Chemistry and Molecular Biology Alexander Rich and Norman Davidson
  • The Chemical Foundations of Molecular :James D. Watson
  • Human Cytogenetic Techniques and Clinical Applications HemaPurandare and Arnit Chakravarty
  • Progress in Nucleic Acid Research and Molecular Biology Vol. 9 J. N. Davidson
  • Essentials of Human Genetics Bhatnagar,Kothari,Mehta

 

  • Principles and Practice of Medical Genetics, by Emery, A.E.H and D.L. Rimoin (Eds_ (1990-2nd edition) Churchill Livingstone, Edinburgh.
  • Molecular Basis of Inherited Diseases, (6th Edition-1989) by Scriver, C.R. A.L. Beudit,

W.S. Sty ab nd D. Valle (Eds0 McGrawHill, New York.

  • Human Genetics by S.D. Gangane (2nd edition-Reprint 2001), B.L Churchill Livingstone Pvt. Ltd., New Delhi.
  • Genetics in Medicine by M.W. Thompson et al, 5th Edition, W.B. Sounders Company, London
  • Genetic basis of common diseases by R. A. King et al, Oxford University Press.
  • Mendelian inheritance in Man by Mc. Kusick V.A. (1998), 12th Edition, John Hopsins University Press, Baltimore.

 

e- RESOURCES:

 

e- JOURNAL:

  • Molecular and Cellular Biology
  • BMC Cell and Molecular Biology- ISSN: 2661-8850

 

Academic Year: 
2023-2024
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