CELL AND MOLECULAR BIOLOGY II (Theory)

Paper Code: 
24ZOL423B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
Course objectives:
This course will enable the students to –
1. Appraise the detailed knowledge of our immune system to defend against invading pathogens in a logical fashion.
2. Differentiate and evaluate between innate and acquired immunity; Humoral and cell mediated immunity and the consequences of its failure like autoimmunity, hypersensitivity and immunodeficiencies.
3. Develop an understanding about the role of effector cells and molecules of the immune system as complements and antibodies.
 
Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Course Code

Course Title

 

 

 

 

 

 

 

 

 

 

 

 

24ZOL

423 (B)

 

 

 

 

 

 

 

 

 

 

 

 

Cell And Molecular Biology II (Theory)

 

The student will

CO163. Conceptualize how                                                the innate and adaptive

immune responses coordinate                                                  to fight invading pathogens and cell and organs of immune system CO164. Develop an

understanding                                    about immunoglobulin    structure                              and functions and antibody diversity CO165. Appraise the

antigen and

antibody specific            interactions, MHC and mechanism of humoral and cell mediated immunity CO166. List antigen processing and            presentation               pathways, cytokines and complement system and

hypersensitivity reactions.

CO167. Develop the concept of vaccines, immunodeficiency and autoimmune diseases.

CO168. Contribute effectively in course-specific interaction

Approach in teaching: Interactive Lectures,

Reading assignments, Demonstration, Learning activities for the students: Self- learning

assignments, Effective questions, Seminar presentation,

Class test Semester end examinations, Quiz Assignments, Presentations Surprise test Open book Test

 

12.00
Unit I: 
UNIT I
Molecular Immunology.
● Innate (nonspecific)immunity. o Adaptive (specific)Immunity.
Cells and organs of the immune system.
● Hematopoiesis
● B-lymphocytes, T-lymphocytes, Null cells.
● Mononuclear cells
● Granulocytic cells
● MastCells.
● Dendritic cells.
Organs of the immune system: Lymphatic system.
● Primary lymphoid organs
● Secondary lymphoid organs Antigens. Immunogenicity versus antigenicity.
● Factors influence immunogenicity
● Contribution of Biological system. (Genotype of the recipient animal, immunogen dosage and route of administration, adjuvants).
● Epitopes
● Haptans.
 
12.00
Unit II: 
Unit II

Immunoglobulins : Structure and function.

  • Molecular structure of Ig, Light chain and Heavy chain
  • Immunoglobulin domains.
  • Immunoglobulin classes
  • Immunoglobulin-mediated effector functions
  • Antigenic determinants on immunoglobulin (isotype, allotype and idiotype). Generation of antibody diversity.
  • Multiple germline V, D and J gene segments.
  • Combinatorial V-J and V-D-Jjoining.
  • Junctional flexibility.
  • P-addition and N-addition.
  • Association of heavy and light chains. Class switching among constant region genes. ● Expression of Ig genes.
  • Regulation of Ig gene transcription.

 

12.00
Unit III: 
Unit III
Antigen-Antibody Interaction.(in vivo and in vitro) Major Histocompatibility complex.
● General organization and inheritance of MHC.
● Genomic maps of MHC genes.
● MHC molecules and genes.
● Cellular distribution of MHC molecules.
● MHC and disease susceptibility.
Mechanism of Humoral and cell mediated immunity
 
12.00
Unit IV: 
Unit IV
Antigen Processing and Presentation.
● Role of antigen presenting cell.
● The cytosolic pathways. Endogenous antigens:
● The endocytic pathway Exogenous antigens
 
● Presentation of nonpeptide bacterial antigens. Cytokines: general structure properties and functions
● Cytokine related diseases. Complement system Hypersensitivity
 
12.00
Unit V: 
Unit V
Vaccine.
● Active and passive immunization
● Types of vaccines
AIDS and other immunodeficiencies.
Autoimmunity: Proposed mechanisms for induction of autoimmunity
● Systemic autoimmune diseases
● Organ specific autoimmune disease
 
Essential Readings: 
● Roitt’s essential Immunology, P. Delves, et al., 11th ed., Blackwell Publishing, 2006
● Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006). Immunology, VI Edition. W.H. Freeman and Company.
 
References: 
SUGGESTED READINGS:
● David, M., Jonathan, B., David, R. B. and Ivan R. (2006). Immunology,VII Edition, Mosby, Elsevier Publication.
● Abbas, K. Abul and Lechtman H. Andrew (2017) Cellular and Molecular Immunology. V Edition. Elsevier; 9th edition
e-RESOURCES:
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e-JOURNAL:
● Immunology- Wiley online Library- ISSN 1365-2567
● Scandinavian Journal of Immunology-Online ISSN: 1365-3083
 
Academic Year: 
2024-2025
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