Cell and Molecular Biology II

Paper Code: 
ZOL 423B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 423 (B)

Cell And Molecular Biology II

Students will :

CO136: Conceptualize how the innate and adaptive immune responses coordinate to fight invading pathogens.

CO137: Demonstrate how  immunomodulatory strategies can be used to enhance immune responses or to suppress unwanted immune responses

CO138: Develop an understanding about hypersensitivity reactions, transplantations or autoimmune diseases.

CO139:Appraise the structure of antigen and antibody and their specific interactions.

CO140: Design strategies to improve existing vaccines and how to approach these.

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

 

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks, Field practical

 

Class test

Semester end examinations,

Quiz

Assignments,

Presentations

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I
Molecular Immunology.
● Innate (nonspecific)immunity.
o Adaptive (specific)Immunity.
Cells and organs of immune system.Hematopoiesis
● B-lymphocytes, T-lymphocytes, Nullcells.
● Mono nuclear cells
● Granulocytic cells
● MastCells.
● Dendritic cells. Organs of immune system. Lymphatic system.
● Primary lymphoid organs
● Secondary lymphoid organsAntigens.
● Immunogenicity versus antigenicity.
● Factors influence immnogenicity
● Contribution of  Biological  system. (Genotype of therecipient animal, immunogen dosage and route of administration, adjuvants).
● Epitopes
● Haptans.
12.00
Unit II: 
UNIT II

Immunoglobulins : Structure and function.

  • Molecular structure of Ig, Light chain and Heavy chain
  • Immuno globulindomains.
  • Immuno globulinclasses
  • Immunoglobulin-mediated                  effector    functions
  • Antigenic determinants on immunoglobulin (isotype, allotype and idiotype).

Generation of antibody diversity.

  • Multiple germ line V, D and J gene segments.
  • Combinatorial V-J and V-D-Jjoining.
  • Junctional flexibility.
  • P-addition andN-addition.
  • Association of heavy and light chain. Class switching among constant region genes.
  • Expression of Ig genes.
  • Regulation of Ig gene transcription.

Antibody genes and antibody engineering.

 

12.00
Unit III: 
UNIT III

Antigen-Antibody Interaction.(in vivo and in vitro) Major Histocompatibility complex.

  • General organization and inheritance ofMHC.
  • Genomic maps of MHCgenes.
  • MHC molecules and genes.
  • Cellular distribution of MHCmolecules.
  • MHC and disease susceptibility.
  • Mechanism of Humoral and cell mediated immunity
12.00
Unit IV: 
UNIT IV

Antigen Processing and Presentation.

  • Role of antigen presenting cell.
  • The cytosolic pathways. Endogenous antigens:
    • The endocytic pathway Exogenous antigens
  • Presentation of nonpeptide bacterial antigens. Cytokines: general structure properties and functions
  • Cytokine related diseases.
  • Complement system
  • Hypersensitivity
12.00
Unit V: 
UNIT V

Vaccine.

  • Active and passive immunization
  • Types of vaccines

AIDS and other immunodeficiencies.

Autoimmunity: Proposed mechanisms for induction of autoimmunity

  • Systemic autoimmune diseases
  • Organ specific autoimmune disease
Essential Readings: 
 

● Roitt’s essential Immunology, P. Delves, et al., 11th ed., Blackwell Publishing, 2006

● Kindt, T. J., Goldsby, R.A., Osborne, B. A. and Kuby, J (2006). Immunology, VI Edition.  W.H. Freeman and Company.

SUGGESTED READINGS:

● David, M., Jonathan, B., David, R. B. and Ivan R. (2006). Immunology,VII Edition, Mosby,  Elsevier Publication.

● Abbas, K. Abul and Lechtman H. Andrew (2017) Cellular and Molecular Immunology. V  Edition. Elsevier; 9th edition

e-RESOURCES:

e-Journal:

  • Immunology- Wiley online Library- ISSN 1365-2567
  • Scandinavian Journal of Immunology-Online ISSN: 1365-3083

 

Academic Year: 
2023-2024
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