Cell and Molecular Biology

Paper Code: 
ZOL-323(B)
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00

Biomembranes.

  • Phospholipids : main lipid constituent.
  • Cytosolic and exoplasmic face of biomembranes.
  • Intrinsic and extrinsic proteins.

 

  •  Glycolipids.
  • Mobility of lipids and integral proteins
  • Fluidity of bio membrane.
  • Cell Junctions (Gap, tight and desmosomes )

Transport across cell membrane.

  •   Diffusion of small molecules.
  • Osmosis and water channels.
  • Uniporter-catalyzed transport.
  • Active Transport.
  • Cotransport by symporters and antiporters.
 
12.00

Cytoskeleton:Structure ,Function and Dynamics of

  • Microfilaments:Actin and Myosin
  • Microtubule and mitosis.
  • Kinesin and Dynein.
  • Intermediate Filaments

Cilia and Flagella.

  • Structure and movements

Cell-Cell Signaling.

  • Endocrine, paracrine, autocrine signaling.
  • Receptor    Proteins-    Intracellular receptors.

     Cell surface receptors-G-protein coupled    receptors, ion channel receptors, tyrosine kinase  linked  receptors and receptors with
intrinsic enzymatic activity.

 

  • Second messenger system-cAMP and IP3 DAG and MAP kinase pathways.

 

Signal-Mediated transport through Nuclear Pore.

  • Nuclear Pore Complex.
  • Nuclear export signals.
 

Nuclear localization signals

12.00

Cell-Cell adhesion and communication.

  • Cadherin mediated Ca- dependent homophilic cell-cell adhesion.
  • N-CAMs mediate Ca-independent homophilic cell-cell adhesion.
  •  Connexin.

Cell matrix adhesion.

  • Integrins
  • Collagen
  • Non-collagen   components   of   extracellular   matrix  

Cell cycle.

  • Eukaryotic cell cycle-Gl, S, G2 and M phases.
  • Cell cycle and check points.
  • Molecular basis of cell cycle regulation.

 

  Cyclins and cyclin-dependent kinases.
 

  Regulation of CDK-cyclin activity

12.00



Cancer.

·                  Tumor cells and the onset of cancer.

·                  Proto-oncogenesis and tumor suppressor genes.

·                  Mutation causing loss of cell cycle.

·                  Mutations affecting genome stability.

 

Aging: The biology of senescence.

·                  Maximum life span and life expectancy.

·                  Causes of aging

Cell Death.

Apoptosis and necrosis.

12.00

Molecular structure of genes and chromosomes.

  • Molecular definition of gene.
  • Chromosomal organization of genes and non-coding DNA.
  • Mobile DNA.
  • Functional rearrangement of chromosomal DNA
  • Morphological     and     functional      elements      of     eukaryotic chromosomes.

Regulation of Gene Expression.

  • Operon concept.
  • Catabolic repression.
  • Positive and Negative regulation.
  • Inducers and co-repressors.

 

DNA binding proteins and gene regulation.

  • DNA binding domains.
  • Homeo domain proteins.
  • Zinc finger proteins.
  • Winged-helix (Forked head) proteins.
  • Leucine-Zipper proteins.
  • Helix-loop-helix proteins.
 
Academic Year: 
2016-2017
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