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Cancer Biology
Paper Code:
LSC 144 J
Credits:
4
Contact Hours:
60.00
Max. Marks:
100.00
12.00
Unit I:
BIOLOGY OF CANCER
Cell cycle and cancer, the nature and types of cancer
Cellular oncogenes and Tumor suppressor genes: DNA viruses, retroviruses, proto oncogenes, tumor suppressor genes, pRb and control of the cell cycle clock, p53 and apoptosis
Tumor immunology: immune mediated disease (hypersensitivity and autoimmunity
12.00
Unit II:
TOXICITY AT CELLULAR LEVEL AND ENZYMOLOGY INVOLVED
Mechanism of toxicity: toxicity of O2, xenobiotics, mutagens and carcinogens
Multistage carcinogenesis: chemical carcinogens-genotoxic, nongenotoxic and inorganic carcinogens
Biotransformation of xenobiotics through liver detoxification (Phase I and II)
Mechanism of repair (molecular and cellular), toxicity resulting from inappropriate repair
12.00
Unit III:
PRINCIPLES OF CANCER TREATMENT
Natural history of cancer therapy, ethical and philosophical issues
Treatment available: surgery, radiation, chemotherapy, biological therapy, gene therapy
12.00
Unit IV:
PRINCIPLES OF CANCER SCREENING AND CHEMOPREVENTION OF CANCER
Screening of cancer and the biases of screening, screening of specific cancers
Chemoprevention: Chemopreventive agents from natural products, preclinical animal model selection, phytopharmaceuticals in cancer chemoprevention
12.00
Unit V:
TEST SYSTEMS/ASSAYS USED IN CANCER
Carcinogenicity assessment: short term tests for mutagenicity, chronic testing for carcinogenicity and transgenic animals in carcinogenicity assessment
Assays for detecting genetic alterations: DNA damage and repair assays, genetic alteration in mammals, mammalian cytogenetic assays, germ cell mutagenesis
New approaches to genetic toxicology
Essential Readings:
Casarett & Doull’s (7th ed ) Toxicology: The basic Science of Poisons, Curtis D. Klassen
• Haskell: Caner Treatment (4th Ed), W.B Saunders Company, Mc. Graw Hill.
• Pecckham, Pinedo and Veronesi: Oxford Textbook of Oncology,Vol:1 and 2.
• Chemoprevention of Cancer and DNA Damage by Dietary Factors: Edited by Siegfried Knasmüller, David M. DeMarini, Ian Johnson, and Clarissa Gerhäuser. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Academic Year:
