CANCER AND RADIATION BIOLOGY I

Paper Code: 
24ZOL323A
Credits: 
4
Contact Hours: 
4.00
Max. Marks: 
100.00
Objective: 
Course objectives:
This course will enable the students to –
1. Acquainted with the detailed knowledge of types of cancer and their causes
2. Explain the role of radiations in cancer and their treatment.
 
Course Outcomes: 

Course

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Course Code

Course Title

 

24ZOL

323 A

Cancer And Radiation Biology I

(Theory)

 

CO85.To describe  types  of

cancer and their causes

CO86. Predict stages and

grading of cancer

CO87. Conclude Cancer cell

growth    patterns    and    cell

kinetics

CO88. Infer the role of Radiations in cancer and their treatment.

CO89. Cellular radiobiology and  Cytogenetic  effects  of

radiation.

CO90. Contribute effectively

in course-specific interaction

Approach in

teaching:

Interactive lectures,

Discussion, Tutorials

Reading assignments,

Demonstration,

Team teaching

Learning activities for the students: Self-learning

assignments,

Effective questions,

Simulation, Seminar

presentation,

Giving tasks

Class test

Semester    end

examinations,

Quiz

Assignments,

Presentation

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I
Introduction: Cancer as a cellular disease.
● Historical perspective.
● Cancer Causation.
● Cancer Treatment.
● Death due to cancer. Occurrence of cancer.
● Present day status of cancer in India.
● Status of cancer occurrence in different parts of the world.
● Cancer of different sex.
● Cancer of different age groups. Tumor Classification.
● Benign and malignant tumors.
● Sarcoma,carcinoma.
 
● Leukemia andlymphoma.
● Ascites Tumors.
● Teratocarcinoma.
 
12.00
Unit II: 
Unit II
Staging and grading of cancer.
● In vitro cell transformation.
● Apoptosis Cancer cell:
● Structural and ultrastructural profiles.
● Biochemical Properties.
● Behavior properties. Genetic basis of cancer:
● Basic concepts of cancer genetics.
● Relationship between cancer incidence and age.
● Cellular and genetic basis of cancer.
● Types of genetic risk factors for cancer.
● Chromosomal abnormalities in tumors.
● Heritable cancer and tumor suppressor. Oncogene
● Introduction.
● Detection of oncogenes in human cancer cells
● Activation of oncogenes.
● Antioncogenes
 
12.00
Unit III: 
Unit III
● Cancer cell growth patterns and cell kinetics:
● Tumor Growth.
● Cell Cycle.
● Cell proliferation in tumor tissue.
● Experimental Tumor.
● Human Tumors.
● Cell proliferation, prognosis and therapies.
● Cell proliferation, prognosis and therapies.
● MetastasisIntroduction.
● Metastatic Process.
● Metastatic ability of tumor cell population.
● Properties of metastatic cell.
● Genetic basis of metastasis.
 
12.00
Unit IV: 
Unit IV
Introduction to radiation
● Types –ionizing and non-ionizing
● Sources- Natural and Manmade
● Radiation dosimetry Radiation chemistry
● Hydrogen peroxide formation.
● Reactions in aqueous organic solutions.
● Direct and indirect effects.
● Oxygeneffect
 
12.00
Unit V: 
Unit V
Cellular radiobiology.
● Survival Curves.
● Radiosensitivity of cell cycle phases.
● Factors influencing radio sensitivity (oxygen effect chemical modifiers). Cytogenetic effects of radiation.
● Chromosomal aberrations.
 
● Micronuclei Induction.
● Radiation Mutations.
 
Essential Readings: 
• RameshaRao. : Who runs the risk of cancer.Shipra Publication.
• Alberts. B. Bras D. lenis J. : Molecular Biology of the cells. Govland Publishing New York.
• Devita VT. Cancer Prevention. Hellmos. Rosensey. S.A. J.B. Lippincott.
• Hall. E. J. Radiobiology for the radiobiologists. Lippincott. Philadelphia.
• P.S. Lotran. V. Kumar. T.collins. : Pathology of Diseases Robbins.
 
References: 
SUGGESTED READINGS:
• Peekham. M.. Herbert M. Pinedo. Umberto Veronesi. : Oxford textbook of oncology Vol. I.. Vol. II. Oxford Medical Publication. Oxford University Press. Inc. New York 1995.
• Tannode. 1 F and Richand P. : The Basic science of oncology. ThII. MacGraw-Hill
• Vinay Kumar. Ramzi. S. Cotran and Stranley L. Robbins. : Basic pathology.
• Thomson press Ltd.. NOIDA. 1999.
• Weiss. L. : Principles of metastases. Acdemic press.
 
E-RESOURCES:
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JOURNALS:
 
Academic Year: 
2024-2025
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