Cancer and Radiation Biology I

Paper Code: 
ZOL 323 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

 

 

 

ZOL 323 A

 

 

 

Cancer And Radiation Biology I

Students will –

CO72: To describe types of cancer and their causes

CO73:  Infer the role of Radiations in cancer and their treatment.

CO74 : Predict stages and grading of cancer

CO75: Conclude Cancer cell growth patterns and cell kinetics.

CO76: Cellular radiobiology and Cytogenetic effects of radiation.

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks

 

Class test

Semester end examinations,

Quiz

Assignments,

Presentation

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I

Introduction: Cancer as a cellular disease.

  • Historical perspective.
  • Cancer Causation.
  • Cancer Treatment.
  • Death due to cancer. Occurrence of cancer.
  • Present day status of cancer in India.
  • Status of cancer occurrence in different parts of the world.
  • Cancer of different sex.
  • Cancer of different age groups. Tumor Classification.
  • Benign and malignant tumors.
  • Sarcoma,carcinoma.
  • Leukemia andlymphoma.
  • Ascites Tumors.
  • Teratocarcinoma.
12.00
Unit II: 
UNIT II
Staging and grading of cancer.
In vitro cell transformation.
Apoptosis
Cancer cell:
Structural and ultrastructural profiles.
Biochemical Properties.
Behavior properties. Genetic basis of cancer:
Basic concepts of cancer genetics.
Relationship between cancer incidence and age.
Cellular and genetic basis of cancer.
Types of genetic risk factors for cancer.
Chromosomal abnormalities in tumors.
Heritable cancer and tumor suppressor. Oncogene
Introduction.
Detection of oncogenes in human cancer cells
Activation of oncogenes.
Antioncogenes
12.00
Unit III: 
UNIT III
  • Cancer cell growth patterns and cell kinetics:
  • Tumor Growth.
  • Cell Cycle.
  • Cell proliferation in tumor tissue.
  • Experimental Tumor.
  • Human Tumors.
  • Cell proliferation, prognosis and therapies.
  •  Cell proliferation, prognosis and therapies.
  •   MetastasisIntroduction.
  • Metastatic Process.
  • Metastatic ability of tumor cell population.
  • Properties of metastatic cell.
  • Genetic basis of metastasis.

 

12.00
Unit IV: 
UNIT IV

 Introduction to radiation

  • Types –ionizing and non-ionizing
  • Sources- Naturaland Manmade
  • Radiation dosimetry

Radiation chemistry

  • Hydrogen peroxide formation.
  • Reactions in aqueous organic solutions.
  • Direct and indirect effects.
  • Oxygeneffect.
12.00
Unit V: 
UNIT V

Cellular radiobiology.

  • Survival Curves.
  • Radiosensitivity of cell cycle phases.
  • Factors influencing radio  sensitivity (oxygen      effect   chemical modifiers).

Cytogenetic effects of radiation.

  • Chromosomal aberrations.
  • Micronuclei Induction.
  • Radiation Mutations.
Academic Year: