Cancer and Radiation Biology I

Paper Code: 
ZOL 323 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to –

  1. Acquaint with the detailed knowledge of types of cancer and their causes
  2. Explain the role of radiations in cancer and their treatment.

 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

 

 

 

ZOL 323 A

 

 

 

Cancer And Radiation Biology I

Students will –

CO72: To describe types of cancer and their causes

CO73:  Infer the role of Radiations in cancer and their treatment.

CO74 : Predict stages and grading of cancer

CO75: Conclude Cancer cell growth patterns and cell kinetics.

CO76: Cellular radiobiology and Cytogenetic effects of radiation.

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks

 

Class test

Semester end examinations,

Quiz

Assignments,

Presentation

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I

Introduction: Cancer as a cellular disease.

  • Historical perspective.
  • Cancer Causation.
  • Cancer Treatment.
  • Death due to cancer. Occurrence of cancer.
  • Present day status of cancer in India.
  • Status of cancer occurrence in different parts of the world.
  • Cancer of different sex.
  • Cancer of different age groups. Tumor Classification.
  • Benign and malignant tumors.
  • Sarcoma,carcinoma.
  • Leukemia andlymphoma.
  • Ascites Tumors.
  • Teratocarcinoma.

 

12.00
Unit II: 
UNIT II
Staging and grading of cancer.
● In vitro cell transformation.
● Apoptosis
Cancer cell:
● Structural and ultrastructural profiles.
● Biochemical Properties.
● Behavior properties. Genetic basis of cancer:
● Basic concepts of cancer genetics.
● Relationship between cancer incidence and age.
● Cellular and genetic basis of cancer.
● Types of genetic risk factors for cancer.
● Chromosomal abnormalities in tumors.
● Heritable cancer and tumor suppressor. Oncogene
● Introduction.
● Detection of oncogenes in human cancer cells
● Activation of oncogenes.
● Antioncogenes
 
12.00
Unit III: 
UNIT III
  • Cancer cell growth patterns and cell kinetics:
  • Tumor Growth.
  • Cell Cycle.
  • Cell proliferation in tumor tissue.
  • Experimental Tumor.
  • Human Tumors.
  • Cell proliferation, prognosis and therapies.
  •  Cell proliferation, prognosis and therapies.
  •   MetastasisIntroduction.
  • Metastatic Process.
  • Metastatic ability of tumor cell population.
  • Properties of metastatic cell.
  • Genetic basis of metastasis.

 

12.00
Unit IV: 
UNIT IV

 Introduction to radiation

  • Types –ionizing and non-ionizing
  • Sources- Naturaland Manmade
  • Radiation dosimetry

Radiation chemistry

  • Hydrogen peroxide formation.
  • Reactions in aqueous organic solutions.
  • Direct and indirect effects.
  • Oxygeneffect.

 

12.00
Unit V: 
UNIT V

Cellular radiobiology.

  • Survival Curves.
  • Radiosensitivity of cell cycle phases.
  • Factors influencing radio  sensitivity (oxygen      effect   chemical modifiers).

Cytogenetic effects of radiation.

  • Chromosomal aberrations.
  • Micronuclei Induction.
  • Radiation Mutations.

 

 

Academic Year: 
2022-2023
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