Cancer and Radiation Biology I

Paper Code: 
ZOL 323 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 
Course objectives:
This course will enable the students to –
 
  1. Acquaint with the detailed knowledge of types of cancer and their causes
  2. Explain the role of radiations in cancer and their treatment.
Course Outcomes (COs):
 

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

 

 

 

ZOL 323 A

 

 

 

Cancer And Radiation Biology I

Students will –

CO72: Describe types of cancer and their causes

CO73:  Infer the role of Radiations in cancer and their treatment.

CO74 : Predict stages and grading of cancer

CO75: Conclude Cancer cell growth patterns and cell kinetics.

CO76: Explain about Cellular radiobiology and Cytogenetic effects of radiation.

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks

 

Class test

Semester end examinations,

Quiz

Assignments,

Presentation

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I :
Introduction: Cancer as a cellular disease.
 
● Historical perspective.
● Cancer Causation.
● Cancer Treatment.
● Death due to cancer. Occurrence of cancer.
● Present day status of cancer in India.
● Status of cancer occurrence in different parts of the world.
● Cancer of different sex.
● Cancer of different age groups. Tumor Classification.
● Benign and malignant tumors.
● Sarcoma, carcinoma.
● Leukemia and lymphoma.
● Ascites Tumors.
● Teratocarcinoma.
 
12.00
Unit II: 
UNIT II :
Staging and grading of cancer.
 
  • In vitro cell transformation.
  • Apoptosis
Cancer cell:
 
  • Structural and ultrastructural profiles.
  • Biochemical Properties.
  • Behavior properties. Genetic basis of cancer:
  • Basic concepts of cancer genetics.
  • Relationship between cancer incidence and age.
  • Cellular and genetic basis of cancer.
  • Types of genetic risk factors for cancer.
  • Chromosomal abnormalities in tumors.
  • Heritable cancer and tumor suppressor. Oncogene
  • Introduction.
  • Detection of oncogenes in human cancer cells
  • Activation of oncogenes.
  • Antioncogenes
 
12.00
Unit III: 
UNIT III
  • Cancer cell growth patterns and cell kinetics :
  • Tumor Growth.
  • Cell Cycle.
  • Cell proliferation in tumor tissue.
  • Experimental Tumor.
  • Human Tumors.
  • Cell proliferation, prognosis and therapies.
  • Cell proliferation, prognosis and therapies. 
  • Metastasis Introduction.
  • Metastatic Process.
  • Metastatic ability of tumor cell population.
  • Properties of metastatic cell.
  • Genetic basis of metastasis.
 
12.00
Unit IV: 
UNIT IV
 Introduction to radiation
  • Types –ionizing and non-ionizing
  • Sources- Natural and Manmade
  • Radiation dosimetry
Radiation chemistry
  • Hydrogen peroxide formation.
  • Reactions in aqueous organic solutions.
  • Direct and indirect effects.
  • Oxygen effect.
12.00
Unit V: 
UNIT V
Cellular radiobiology.
  • Survival Curves.
  • Radiosensitivity of cell cycle phases.
  • Factors influencing radio sensitivity (oxygen effect chemical modifiers).
Cytogenetic effects of radiation.
  • Chromosomal aberrations.
  • Micronuclei Induction.
  • Radiation Mutations.
Academic Year: 
2021-2022
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