Cancer and Radiation Biology I

Paper Code: 
ZOL 323 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00
Unit I: 
UNIT I

Introduction : Cancer as a cellular disease.

  • Historical perspective.

·                  Cancer causation.

·                  Cancer treatment.

·                  Death due to cancer.

 Occurrence of cancer.

·                  Present day status of cancer in India.

·         Status of cancer occurrence in different parts of the world.

·                  Cancer of different sex.

·         Cancer of different age groups.

Tumor classification.

·                  Benign and malignant tumors.

·                  Sarcoma, carcinoma.

·                  Leukemia and lymphoma.

·         Ascites tumors.

Teratocarcinoma.

12.00
Unit II: 
UNIT II

Staging and grading of cancer.

  • In vitro cell transformation.
  • Apoptosis

Cancer cell :

  • Structural and ultrastructural profiles.
  • Biochemical properties.
  • Behavior properties.

Genetic basis of cancer :

  • Basic concepts of cancer genetics.
  • Relationship between cancer incidence and age.
  • Cellular and genetic basis of cancer.
  • Types of genetic risk factor for cancer.
  • Chromosomal abnormalities in tumor.
  • Heritable cancer and tumor suppressor.

Oncogene

·                  Introduction.

·                  Detection of oncogenes in human cancer cells,.

·                  Activation of oncogenes.

Antioncogenes

12.00
Unit III: 
UNIT III

Cancer cell growth patterns and cell kinetics :

·                  Tumor growth.

·                  Cell cycle.

·                  Cell proliferation in tumor tissue.

·                  Experimental tumor.

·                  Human tumors.

·                  Cell proliferation, prognosis and therapies.

·         Cell proliferation, prognosis and therapies.

Metastasis

  • Introduction.
  • Metastatic process.
  • Metastatic ability of tumor cell population.
  • Properties of metastatic cell.

Genetic basis of metastasis

12.00
Unit IV: 
UNIT IV

Introduction to radiation

  • Types –ionizing and non-ionizing
  • Sources- Natural andManmade
  • Radiation dosimetry

Radiation chemistry

Radiolysis of water.

  • Hydrogen peroxide formation.
  • Reactions in aqueous organic solutions.
  • Direct and indirect effects.
  • Oxygen effect.

 

12.00
Unit V: 
UNIT V

Cellular radiobiology.

  • Survival curves.
  • Radiosensitivity of cell cycle phases.
  • Factors    influencing    radio    sensitivity    (oxygen    effect    chemical modifiers).

Cytogenetic effects of radiation.

  • Chromosomal aberrations.
  • Micronuclei induction.

Radiation mutations

Essential Readings: 

RameshaRao. : Who runs the risk of cancer.Shipra Publication.

✔   Alberts. B. Bras D. lenis J. : Molecular Biology of the cells. Govland Publishing New York.

✔   Devita VT. Cancer Prevention. Hellmos. Rosensey. S.A. J.B. Lippincott.

✔   Hall. E. J. Radiobiology for the radiobiologists. Lippincott. Philadelphia.

✔   P.S. Lotran. V. Kumar. T.collins. : Pathology of Diseases Robbins.

✔   Peekham. M.. Herbert M. Pinedo. Umberto Veronesi. : Oxford textbook of oncology Vol. I.. Vol. II. Oxford Medical Publication. Oxford University Press. Inc. New York 1995.

✔   Tannode. 1 F and Richand P. : The Basic science of oncology. ThII. MacGraw-Hill

✔   Vinay Kumar. Ramzi. S. Cotran and Stranley L. Robbins. : Basic pathology.

Thomson press Ltd.. NOIDA. 1999.

✔   Weiss. L. : Principles of metastases. Acdemic press.

 

Academic Year: 
2015-2016
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