CANCER AND RADIATION BIOLOGY I

Paper Code: 
ZOL 323 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

 

Course objectives:

This course will enable the students to -

  1. To provide students with a detailed knowledge of types of cancer and their causes
  2. Role of radiations in cancer and their treatment.

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

ZOL 323 A

Cancer And Radiation Biology I

Students should be able

CO54: To describe types of cancer and their causes

CO55:  Role of radiations in cancer and their treatment.

 

Approach in teaching:

Interactive Lectures, Discussion, Tutorials, Reading assignments, Demonstration, Team teaching

 

Learning activities for the students:

Self-learning assignments, Effective questions, Simulation, Seminar presentation, Giving tasks

 

Class test

Semester end examinations,

Quiz

Assignments,

Presentation

Surprise test

Open book test

 

12.00
Unit I: 
UNIT I

Introduction : Cancer as a cellular disease.

  •     Historical perspective.
  •     Cancer causation.
  •     Cancer treatment.
  •     Death due to cancer.

 Occurrence of cancer.

  •     Present day status of cancer in India.
  •     Status of cancer occurrence in different parts of the world.
  •     Cancer of different sex.
  •     Cancer of different age groups.

Tumor classification.

  •     Benign and malignant tumors.
  •     Sarcoma, carcinoma.
  •     Leukemia and lymphoma.
  •     Ascites tumors.
  •     Teratocarcinoma.

 

12.00
Unit II: 
UNIT II

Staging and grading of cancer.

    In vitro cell transformation.

    Apoptosis

Cancer cell :

    Structural and ultrastructural profiles.

    Biochemical properties.

    Behavior properties.

Genetic basis of cancer :

    Basic concepts of cancer genetics.

    Relationship between cancer incidence and age.

    Cellular and genetic basis of cancer.

    Types of genetic risk factor for cancer.

    Chromosomal abnormalities in tumor.

    Heritable cancer and tumor suppressor.

Oncogene

    Introduction.

    Detection of oncogenes in human cancer cells,.

    Activation of oncogenes.

    Antioncogenes

 

12.00
Unit III: 
UNIT III

Cancer cell growth patterns and cell kinetics :

    Tumor growth.

    Cell cycle.

    Cell proliferation in tumor tissue.

    Experimental tumor.

    Human tumors.

    Cell proliferation, prognosis and therapies.

    Cell proliferation, prognosis and therapies.

Metastasis

    Introduction.

    Metastatic process.

    Metastatic ability of tumor cell population.

    Properties of metastatic cell.

    Genetic basis of metastasis.

 

12.00
Unit IV: 
UNIT IV

Introduction to radiation

    Types –ionizing and non-ionizing

    Sources- Natural andManmade

    Radiation dosimetry

Radiation chemistry

    Hydrogen peroxide formation.

    Reactions in aqueous organic solutions.

    Direct and indirect effects.

    Oxygen effect.

12.00
Unit V: 
UNIT V

Cellular radiobiology.

    Survival curves.

    Radiosensitivity of cell cycle phases.

    Factors    influencing    radio    sensitivity    (oxygen    effect    chemical modifiers).

Cytogenetic effects of radiation.

    Chromosomal aberrations.

    Micronuclei induction.

    Radiation mutations.

Academic Year: 
2020-2021
  • Printer-friendly version
  • PDF version