Cancer And Radiation Biology I

Paper Code: 
ZOL 323A
12.00
Unit I: 

Introduction : Cancer as a cellular disease.

  • Historical perspective.
  • Cancer causation.
  • Cancer treatment.
  • Death due to cancer.

 Occurrence of cancer.

  • Present day status of cancer in India.
  • Status of cancer occurrence in different parts of the world.
  • Cancer of different sex.
  • Cancer of different age groups.

Tumor classification.

  • Benign and malignant tumors.
  • Sarcoma, carcinoma.
  • Leukemia and lymphoma.
  • Ascites tumors.
  • Teratocarcinoma.
     
12.00
Unit II: 

Staging and grading of cancer.

  • In vitro cell transformation.
  • Apoptosis

Cancer cell :

  • Structural and ultrastructural profiles.
  • Biochemical properties.
  • Behavior properties.

Genetic basis of cancer :

  • Basic concepts of cancer genetics.
  • Relationship between cancer incidence and age.
  • Cellular and genetic basis of cancer.
  • Types of genetic risk factor for cancer.
  • Chromosomal abnormalities in tumor.
  • Heritable cancer and tumor suppressor.

Oncogene

  • Introduction.
  • Detection of oncogenes in human cancer cells,.
  • Activation of oncogenes.
  • Antioncogenes
     
12.00
Unit III: 

Cancer cell growth patterns and cell kinetics :

  • Tumor growth.
  • Cell cycle.
  • Cell proliferation in tumor tissue.
  • Experimental tumor.
  • Human tumors.
  • Cell proliferation, prognosis and therapies.
  • Cell proliferation, prognosis and therapies.

Metastasis

  • Introduction.
  • Metastatic process.
  • Metastatic ability of tumor cell population.
  • Properties of metastatic cell.
  • Genetic basis of metastasis.
     
12.00
Unit IV: 

Introduction to radiation

  • Types – ionizing and non-ionizing
  • Sources- Natural andManmade
  • Radiation dosimetry

Radiation

chemistry.

Radiolysis of water.

  • Hydrogen peroxide formation.
  • Reactions in aqueous organic solutions.
  • Direct and indirect effects.
  • Oxygen effect.
     
12.00
Unit V: 

Cellular radiobiology.

  • Survival curves.
  • Radiosensitivity of cell cycle phases.
  • Factors influencing radio sensitivity  (oxygen effect chemical modifiers).

Cytogenetic effects of radiation.

  • Chromosomal aberrations.
  • Micronuclei induction.
  • Radiation mutations.
     
Academic Year: 
2018-2019
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