Bioinformatics, Computer Applications & Quantitative Biology

Paper Code: 
ZOL 322
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
12.00
Unit I: 
UNIT I
  • The Gene bank sequence database
  • Structure data base
  • Sequence analysis
  • Information retrieval from Biological database
  • NCBI data  model
 

Sequence Alignment and database searching

12.00
Unit II: 
UNIT II

 

  • Practical aspects of multiple sequence alignment
  • Phylogenetic analysis
  • Predictive methods using Protein sequences
  • Predictive methods using Nucleotide sequences

       of Mice and Men: Navigating public physical mapping

  • ACEDB:A database for genome information
  • Submitting DNA sequence to the database
 
12.00
Unit III: 
UNIT III

Computer Basics

  • MS-Office
  • Operating Systems(Unix and DOS)
  • Hardware and Software
  • Multimedia
  • Network Concepts(LAN,WAN)
  • Internet
  • Web Servers, Web Access
  • Security
 

HTML,HTTP

10.00
Unit IV: 
UNIT IV
  • Matrices and vectors(General idea – addition , subtraction, Scalar multiplication, multiplication of matrices)
  • Exponential functions(definition & Graph)
  • Periodic Functions( definition & Graph)
  • Differentiation( Rules of differentiation)
  •  Integration(Rules of indefinite & definite integration)
 

 

14.00
Unit V: 
UNIT V
  • Central tendency-Mean, median and mode
  • Graphical & diagrammatic representation( pie chart, bar diagram, histogram, frequency polygon, frequency curve)
  • Measures of dispersion, range, Q.D, standard deviation and coefficient of variation
  • Probability distribution(Elementary idea about)
 

Elementary idea of sampling distribution

  • Standard error
  • Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)
  •  Simple correlation (Karl Pearson method) & regression
 

ANOVA( 1 way & 2 way classification)

Essential Readings: 
  • Biostatistics: A Foundation for Analysis in Health Sciences, (6th edition), W W Daniel, John Wiley and Sons Inc., 1995.
  • Essential Bioinformatics, Jin Xiong, John Wiley and Sons. 2006.
  • Introduction to Bioinformatics, A Teresa and D P Smith, Prentice Hall, 1999.
  • Statistical Methods in Biology, N T J Bailey, Cambridge University Press, 1995.
  • Statistics for Biologist, R C Campbell, Cambridge University Press, 1989.
  • Bioinformatics, A practical Guide to the Analysis of Genes and Proteins, (2nd edition), A D Baxevanis, and B F Ouellette, John Wiley and Sons, 2002.
  • Fundamentals of Biostatistics, Khan,  Publishing Corporation, 1999
  • Instant notes, Bioinformatics, Westhead, Parish, and Twyman, (1st edition), Bios Scientific Publishers Ltd., 2003.
  • Introduction to Bioinformatics, A M Lesk, Oxford University Press, 2002. 
  • Molecular databases for Protein sequence and Structure studies, J A Sillince and M  Sillince, Springer Verlag, 1991
  • Practical statistics for Experimental Biologists, A C Swardlaw,  John Wiley and sons Inc., 1985
  • Sequence Analysis Primer, Gribskov and Devereux, Stockton Press, 1989

 

Academic Year: 
2015-2016
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