Bioinformatics, Computer Applications & Quantitative Biology

Paper Code:

ZOL-322

Credits:

4

Contact Hours:

60.00

Max. Marks:

100.00

12.00

The Gene bank sequence database
Structure data base
Sequence analysis
Information retrieval from Biological database
NCBI data model

Sequence Alignment and database searching

12.00

Practical aspects of multiple sequence alignment
Phylogenetic analysis
Predictive methods using Protein sequences
Predictive methods using Nucleotide sequences

of Mice and Men: Navigating public physical mapping

ACEDB:A database for genome information
Submitting DNA sequence to the database

12.00

Computer Basics

MS-Office
Operating Systems(Unix and DOS)
Hardware and Software
Multimedia
Network Concepts(LAN,WAN)
Internet
Web Servers, Web Access
Security

HTML,HTTP

10.00

Matrices and vectors(General idea – addition , subtraction, Scalar multiplication, multiplication of matrices)
Exponential functions(definition & Graph)
Periodic Functions( definition & Graph)
Differentiation( Rules of differentiation)
Integration(Rules of indefinite & definite integration)

14.00

Central tendency-Mean, median and mode
Graphical & diagrammatic representation( pie chart, bar diagram, histogram, frequency polygon, frequency curve)
Measures of dispersion, range, Q.D, standard deviation and coefficient of variation
Probability distribution(Elementary idea about)
Elementary idea of sampling distribution
Standard error
Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)
Simple correlation (Karl Pearson method) & regression

ANOVA( 1 way & 2 way classification)

Essential Readings:

Biostatistics: A Foundation for Analysis in Health Sciences, (6^th edition), W W Daniel, John Wiley and Sons Inc., 1995.
Essential Bioinformatics, Jin Xiong, John Wiley and Sons. 2006.
Introduction to Bioinformatics, A Teresa and D P Smith, Prentice Hall, 1999.
Statistical Methods in Biology, N T J Bailey, Cambridge University Press, 1995.
Statistics for Biologist, R C Campbell, Cambridge University Press, 1989.
Bioinformatics, A practical Guide to the Analysis of Genes and Proteins, (2^nd edition), A D Baxevanis, and B F Ouellette, John Wiley and Sons, 2002.
Fundamentals of Biostatistics, Khan, Publishing Corporation, 1999
Instant notes, Bioinformatics, Westhead, Parish, and Twyman, (1^st edition), Bios Scientific Publishers Ltd., 2003.
Introduction to Bioinformatics, A M Lesk, Oxford University Press, 2002.
Molecular databases for Protein sequence and Structure studies, J A Sillince and M Sillince, Springer Verlag, 1991
Practical statistics for Experimental Biologists, A C Swardlaw, John Wiley and sons Inc., 1985
Sequence Analysis Primer, Gribskov and Devereux, Stockton Press, 1989