Bioinformatics, Computer Applications & Quantitative Biology

Paper Code: 
ZOL 322
Unit I: 
  • The Gene bank sequence database
  • Structure data base
  • Sequence analysis
  • Sequence Alignment and database searching
  • Practical aspects of multiple sequence alignment


Unit II: 
  • Phylogenetic analysis
  • Information retrieval from Biological database
  • NCBI data  model
  • Predictive methods using Protein sequences
  • Predictive methods using Nucleotide sequences
  • ACEDB:A database for genome information
  • Submitting DNA sequence to the database


Unit III: 

Computer Basics

  • MS-Office
  • Operating Systems (Unix and DOS)
  • Hardware and Software
  • Multimedia
  • Network Concepts (LAN, WAN)
  • Internet
  • Web Servers, Web Access
  • Security
Unit IV: 
  • Matrices and vectors (General idea – addition, subtraction, Scalar multiplication, multiplication of matrices)
  • Exponential functions (definition & Graph)
  • Periodic Functions (definition & Graph)
  • Differentiation ( Rules of differentiation)
  •  Integration (Rules of indefinite & definite integration)
Unit V: 
  • Central tendency-Mean, median and mode
  • Graphical & diagrammatic representation( pie chart, bar diagram, histogram, frequency polygon, frequency curve)
  • Measures of dispersion, range, Q.D, standard deviation and coefficient of variation
  • Probability distribution(Elementary idea about)
  • Elementary idea of sampling distribution
  • Standard error
  • Tests of significance- t-test(1 population & 2 population test), Chi-square( independence of attributes)
  •  Simple correlation (Karl Pearson method) & regression

ANOVA( 1 way & 2 way classification)

Essential Readings: 
  1. Biostatistics: A Foundation for Analysis in Health Sciences, (6th edition), W W Daniel, John Wiley and Sons Inc., 1995.
  2. Essential Bioinformatics, Jin Xiong, John Wiley and Sons. 2006.
  3. Introduction to Bioinformatics, A Teresa and D P Smith, Prentice Hall, 1999.
  4. Statistical Methods in Biology, N T J Bailey, Cambridge University Press, 1995.
  5. Statistics for Biologist, R C Campbell, Cambridge University Press, 1989.
  6. Bioinformatics, A practical Guide to the Analysis of Genes and Proteins, (2nd edition), A D Baxevanis, and B F Ouellette, John Wiley and Sons, 2002.
  7. Fundamentals of Biostatistics, Khan,  Publishing Corporation, 1999
  8. Instant notes, Bioinformatics, Westhead, Parish, and Twyman, (1st edition), Bios Scientific Publishers Ltd., 2003.
  9. Introduction to Bioinformatics, A M Lesk, Oxford University Press, 2002.  
  10. Molecular databases for Protein sequence and Structure studies, J A Sillince and M  Sillince, Springer Verlag, 1991
  11. Practical statistics for Experimental Biologists, A C Swardlaw,  John Wiley and sons Inc., 1985
  12. Sequence Analysis Primer, Gribskov and Devereux, Stockton Press, 1989
Academic Year: