Biochemistry I

Paper Code: 
ZOL-114
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course objectives:

This course will enable the students to –

1. Examine the properties of water, acid-base nature and types of chemical bonds.

2. Discriminate the structure, classification and cellular metabolic pathways of carbohydrate and lipids. 

3. Judge the principles of bioenergetics and enzyme catalysis along with factors affecting  enzyme activity.

4. Build on their knowledge and understanding about Inborn errors of carbohydrate metabolism, lipid metabolism vitamin deficiency diseases.

Course Outcomes (COs): 

Course 

Learning outcomes 

(at course level)

Learning and  teaching  

strategies

Assessment  

Strategies 

Paper  

Code

Paper Title

ZOL 114 

Biochemistry I 

Students will : 

CO 15: Analyze properties of water,  acid - base nature, and types of  chemical bonds. 

CO 16: Formulate structure,  classification and cellular metabolic  pathways of carbohydrates and  lipids.  

CO 17: Execute the principles of  bioenergetics and enzyme catalysis  along with factors affecting enzyme  activity. 

CO 18: Build on their knowledge  which they will implement about  Inborn errors of carbohydrate  metabolism, lipid metabolism vitamin  deficiency diseases.

The approach  

in teaching: 

Interactive Lectures,  Discussion, Tutorials,  Reading assignments,  Demonstration, Team  teaching 

Learning activities  for the students: 

Self-learning  

assignments,  

presentation, Giving  tasks, 

Class test  

Semester end  examinations, 

Quiz,  

Assignments,  

Presentation 

Surprise test 

Open book test

 

8.00
Unit I: 
UNIT I: Chemistry of biomolecules
● Water as a solvent, Ionization of water, weak acid and weak bases 
● pH and buffer 
● Types of chemical bonding:- 
● Electrovalent ,Covalent and non- covalent bond, H-Bond, Van der Waals interaction,  Hydrophobic interactions 
12.00
Unit II: 
UNIT II: Carbohydrates
● Classification, Structure & properties (monosaccharides and polysaccharides)
● Metabolism- Oxidation of glucose through Glycolysis, Krebs cycle, Gluconeogenesis, and   Oxidative phosphorylation(ETC). 
● Glycogenesis and Glycogenolysis 
10.00
Unit III: 
UNIT III:Lipids
● Classification, (Fatty acids, triglycerides, phospholipids, sphingolipids, Gangliosides,  Glycolipids.) 
● Structure and properties 
● Biosynthesis of Triglycerides, Biosynthesis of Palmitic acid 
● Beta-oxidative pathway of fatty acids 
 
9.00
Unit IV: 
UNIT IV:Enzymes
● Classification, Properties 
● Mechanism of Enzyme action, activation energy 
● Kinetics (Michaelis-Menton Equation) 
● Factors affecting enzyme action 
● Enzyme Inhibition (Competitive and Non- competitive) 
6.00
Unit V: 
UNIT V: Inborn errors of carbohydrate metabolism
● Inborn errors of carbohydrate metabolism:Galactosemia, Lactose Intolerance, Glycogen  storage diseases 
● Inborn errors of lipid metabolism: Niemann pick disease, TaySach’sdisease,Gaucher’s disease,  Krabbe’s disease 
● Vitamins: Occurrence, Function, Requirement, Deficiency diseases 
Essential Readings: 
• U. Satyanarayana . Biochemistry IV Edition, Elsevier (2013) 
• Jain,J.L.Fundamentals of Biochemistry ,S.Chand publishers New Delhi.
• Medical Physiology; Chatterjee, M.N and Shinde, R.; Jaypee brothers.(2007)
• Berg, J. M., Tymoczko, J. L. and Stryer, L. (2006). Biochemistry. VI Edition. W.H Freeman  and Co. 
• Lehninger, A.D. Principles of Biochemistry, CBS Publishers and Distributors, Shahdara, Delhi. 
• Nelson, D. L., Cox, M. M. and Lehninger, A.L. (2009). Principles of Biochemistry. IV Edition.  W.H. Freeman and Co
References: 
SUGGESTED READINGS:
● Harvey, Richard A., Ph. D. (2011). Lippincott's illustrated reviews: Biochemistry. Philadelphia :Wolters Kluwer Health
● Tortora, G.J. and Derrickson, B.H. (2009). Principles of Anatomy and Physiology, XII Edition,  John Wiley & Sons, Inc. 
● Principles of Biochemistry; Smith et.al; McGraw Hill, New York. 
● Textbook of Medical Biochemistry; Ramakrishnan, S. Prasanan, K.G and Rajan, R; Orient  Longman, Madras 
● Conn, E.E. and Stuff, P.K. Outlines of Biochemistry,John Wiley New York. 
● Donald Voet and Judith G. Voet Biochemistry, John Wiley and Sons., New York.  
● H.S. Srivastava, Element of Biochemistry, Rastogi Publications Meerut.  
 
e-RESOURCES: 
• 2014 Kaplan lecture video series on Biochemistry by Dr. Turco-https://afratafreeh.com/sam-turco/
• e-PGPATHSHALA-INFLIBNET CENTRE-
• Biochemistry- Swayam Prabha-https://dth.ac.in/medical/course.php
 
e-JOURNAL: 
• Journal of Biochemistry- ISSN 1756-2651
• Biochemistry- ACS Publication- ISSN 1520-4995
• Journal of  Cellular Biochemistry- Wiley online Library- Online ISSN: 1097-4644
• 76-2651M
• online ISSN 1756-2651
 
Academic Year: 
2022-2023
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